Tumor organoids: Opportunities and challenges to guide precision medicine

被引：230

作者：

Veninga, Vivien ^{[1
,2
]}

Voest, Emile E. ^{[1
,2
]}

机构：

[1] Netherlands Canc Inst, Dept Mol Oncol & Immunol, NL-1066 CX Amsterdam, Netherlands

[2] Oncode Inst, Utrecht, Netherlands

来源：

CANCER CELL | 2021年 / 39卷 / 09期

关键词：

HUMAN COLON; STEM-CELL; LONG-TERM; CULTURES; DISEASE; BIOBANK; MODELS; IMMUNOTHERAPY; DIVERSITY; REVEAL;

D O I：

10.1016/j.ccell.2021.07.020

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor organoids have been proposed as a model system for precision medicine. The ability of tumor organoids to retain characteristics of the original tumor makes them unique for cancer research on an individual patient level. Hence, the idea to use tumor organoids for clinical decision making and optimize patient outcome is tempting. In vitro responses of tumor organoids to a wide array of drugs have been positively correlated to patient responses. However, substantial challenges remain and prospective studies with large cohorts are highly needed before implementation in clinical cancer care can be considered. Because of their personalized characteristics and the immediate link with patient data, tumor organoids also have great potential in preclinical research. Here, we provide a critical overview of both clinical and preclinical advances using tumor organoids.

引用

页码：1190 / 1201

页数：12

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