Treatment planning for a scanned carbon beam with a modified microdosimetric kinetic model

被引：246

作者：

Inaniwa, Taku ^{[1
]}

Furukawa, Takuji ^{[1
]}

Kase, Yuki ^{[1
]}

Matsufuji, Naruhiro ^{[1
]}

Toshito, Toshiyuki ^{[1
]}

Matsumoto, Yoshitaka ^{[1
]}

Furusawa, Yoshiya ^{[1
]}

Noda, Koji ^{[1
]}

机构：

[1] Natl Inst Radiol Sci, Med Phys Res Grp, Res Ctr Charged Particle Therapy, Inage Ku, Chiba 2638555, Japan

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 2010年 / 55卷 / 22期

关键词：

LOCAL EFFECT MODEL; HEAVY-ION BEAMS; TRACK STRUCTURE; CELL-SURVIVAL; PARTICLE THERAPY; IRRADIATION; HIMAC; OPTIMIZATION; RADIATION; RADIOTHERAPY;

D O I：

10.1088/0031-9155/55/22/008

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We describe a method to calculate the relative biological effectiveness in mixed radiation fields of therapeutic ion beams based on the modified microdosimetric kinetic model (modified MKM). In addition, we show the procedure for integrating the modified MKM into a treatment planning system for a scanned carbon beam. With this procedure, the model is fully integrated into our research version of the treatment planning system. To account for the change in radiosensitivity of a cell line, we measured one of the three MKM parameters from a single survival curve of the current cells and used the parameter in biological optimization. Irradiation of human salivary gland tumor cells was performed with a scanned carbon beam in the Heavy Ion Medical Accelerator in Chiba (HIMAC), and we then compared the measured depth-survival curve with the modified MKM predicted survival curve. Good agreement between the two curves proves that the proposed method is a candidate for calculating the biological effects in treatment planning for ion irradiation.

引用

页码：6721 / 6737

页数：17

共 30 条

[1] GEANT4-a simulation toolkit [J].

Agostinelli, S ;

Allison, J ;

Amako, K ;

Apostolakis, J ;

Araujo, H ;

Arce, P ;

Asai, M ;

Axen, D ;

Banerjee, S ;

Barrand, G ;

Behner, F ;

Bellagamba, L ;

Boudreau, J ;

Broglia, L ;

Brunengo, A ;

Burkhardt, H ;

Chauvie, S ;

Chuma, J ;

Chytracek, R ;

Cooperman, G ;

Cosmo, G ;

Degtyarenko, P ;

Dell'Acqua, A ;

Depaola, G ;

Dietrich, D ;

Enami, R ;

Feliciello, A ;

Ferguson, C ;

Fesefeldt, H ;

Folger, G ;

Foppiano, F ;

Forti, A ;

Garelli, S ;

Giani, S ;

Giannitrapani, R ;

Gibin, D ;

Cadenas, JJG ;

González, I ;

Abril, GG ;

Greeniaus, G ;

Greiner, W ;

Grichine, V ;

Grossheim, A ;

Guatelli, S ;

Gumplinger, P ;

Hamatsu, R ;

Hashimoto, K ;

Hasui, H ;

Heikkinen, A ;

Howard, A .

NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2003, 506 (03) :250-303

[2]

Aso T., 2007, NUCL SCI S IEEE C RE, V4, P2564

[3] MICRODOSIMETRIC STRUCTURE OF HEAVY-ION TRACKS IN TISSUE [J].

CHATTERJEE, A ;

SCHAEFER, HJ .

RADIATION AND ENVIRONMENTAL BIOPHYSICS, 1976, 13 (03) :215-227

[4] Improvement of the local effect model (LEM) -: Implications of clustered DNA damage [J].

Elsaesser, Th. ;

Scholz, M. .

RADIATION PROTECTION DOSIMETRY, 2006, 122 (1-4) :475-477

[5] Cluster effects within the local effect model [J].

Elsaesser, Thilo ;

Scholz, Michael .

RADIATION RESEARCH, 2007, 167 (03) :319-329

[6]

FURUKAWA T, 2010, MED PHYS IN PRESS

[7]

Furusawa Y, 2000, RADIAT RES, V154, P485, DOI 10.1667/0033-7587(2000)154[0485:IOAAHC]2.0.CO

[8]

[9] Biological dose optimization with multiple ion fields [J].

Gemmel, A. ;

Hasch, B. ;

Ellerbrock, M. ;

Weyrather, W. K. ;

Kraemer, M. .

PHYSICS IN MEDICINE AND BIOLOGY, 2008, 53 (23) :6991-7012

[10] A microdosimetric-kinetic model for the effect of non-Poisson distribution of lethal lesions on the variation of RBE with LET [J].

Hawkins, RB .

RADIATION RESEARCH, 2003, 160 (01) :61-69

← 1 2 3 →