The role of vitamin D in ovarian cancer: epidemiology, molecular mechanism and prevention

被引：41

作者：

Guo, Hui ^{[1
,2
]}

Guo, Jing ^{[1
,2
]}

Xie, Wenli ^{[1
,3
]}

Yuan, Lingqin ^{[1
]}

Sheng, Xiugui ^{[1
,4
]}

机构：

[1] Shandong Univ, Shandong Acad Med Sci, Dept Gynecol Oncol, Shandong Canc Hosp, Jinan, Shandong, Peoples R China

[2] Univ Jinan, Shandong Acad Med Sci, Sch Med & Life Sci, Jinan, Shandong, Peoples R China

[3] Shandong Univ, Jinan, Shandong, Peoples R China

[4] Chinese Acad Med Sci, Canc Hosp, Shenzhen Ctr, Guangzhou, Guangdong, Peoples R China

来源：

JOURNAL OF OVARIAN RESEARCH | 2018年 / 11卷

关键词：

Ovarian cancer; 1,25(oh)(2)D-3; Angiogenesis; Metastasis; Inflammatory; Tumor metabolism; Prevention; CIRCULATING 25-HYDROXYVITAMIN D; RECEPTOR GENE POLYMORPHISMS; 1,25-DIHYDROXYVITAMIN D-3; DOWN-REGULATION; IN-VITRO; CALCIUM SUPPLEMENTATION; ULTRAVIOLET-RADIATION; LIPID-ACCUMULATION; COLORECTAL-CANCER; BREAST-CANCER;

D O I：

10.1186/s13048-018-0443-7

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Vitamin D is a fat-soluble prohormone best known for its role in maintaining calcium homeostasis. Large numbers of epidemiological studies have shown that vitamin D plays an important role in cancer prevention by regulating cellular proliferation and metabolism. Studies of the cellular mechanism of vitamin D in ovarian cancer strongly suggest that it exhibits protective and antitumorigenic activities through genomic and nongenomic signal transduction pathways. These results indicate that vitamin D deficiency results in an increase in the risk of developing ovarian cancer and that vitamin supplements may potentially be an efficient way of preventing cancer. Consequently, this review describes the epidemiology, molecular mechanism and evidence linking vitamin D deficiency to ovarian cancer.

引用

页数：8

共 90 条

[1] 1,25(OH)2D3 disrupts glucose metabolism in prostate cancer cells leading to a truncation of the TCA cycle and inhibition of TXNIP expression [J].