Developing a toolkit for the assessment and monitoring of musculoskeletal ageing

被引：23

作者：

Kemp, Graham J. ^{[1
,17
]}

Birrell, Fraser ^{[2
,17
]}

Clegg, Peter D. ^{[1
,17
]}

Cuthbertson, Daniel J. ^{[1
,17
]}

De Vito, Giuseppe ^{[14
]}

van Dieen, Jaap H. ^{[3
]}

Del Din, Silvia ^{[4
]}

Eastell, Richard ^{[5
,17
]}

Garnero, Patrick ^{[6
,7
]}

Goljanek-Whysall, Katarzyna ^{[1
,17
]}

Hackle, Matthias ^{[8
]}

Hodgson, Richard ^{[9
]}

Jackson, Malcolm J. ^{[1
,17
]}

Lord, Sue ^{[4
]}

Mazza, Claudia ^{[10
,11
,17
]}

McArdle, Anne ^{[1
,17
]}

McCloskey, Eugene V. ^{[5
,17
]}

Narici, Marco ^{[12
]}

Peffers, Mandy J. ^{[1
,17
]}

Schiaffino, Stefano ^{[13
]}

Mathers, John C. ^{[15
,16
,17
]}

机构：

[1] Univ Liverpool, Dept Musculoskeletal Biol, Fac Hlth & Life Sci, IACD, William Duncan Bldg,6 West Derby St, Liverpool L7 8TX, Merseyside, England

[2] Newcastle Univ, Inst Cellular Med, Musculoskeletal Res Grp, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[3] Vrije Univ Amsterdam, Dept Human Movement Sci, Amsterdam Movement Sci, Van der Boechorststr 9, NL-1081 BT Amsterdam, Netherlands

[4] Newcastle Univ, Clin Ageing Res Unit, Inst Neurosci, Inst Ageing, Campus Ageing & Vital, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England

[5] Univ Sheffield, Mellanby Ctr Bone Res, Sheffield S10 2RX, S Yorkshire, England

[6] Geneva Univ Hosp, Div Bone Dis, CH-1205 Geneva, Switzerland

[7] Fac Med, CH-1205 Geneva, Switzerland

[8] TAmiRNA GmbH, Muthgasse 18, A-1190 Vienna, Austria

[9] Univ Manchester, Ctr Imaging Sci, Stopford Bldg,Oxford Rd, Manchester M13 9PT, Lancs, England

[10] Univ Sheffield, Dept Mech Engn, Sheffield S1 3JD, S Yorkshire, England

[11] Univ Sheffield, INSIGNEO Inst Silico Med, Sheffield S1 3JD, S Yorkshire, England

[12] Derby Royal Hosp, MRC ARUK Ctr Excellence Musculoskeletal Ageing Re, Uttoxeter Rd, Derby DE22 3DT, England

[13] VIMM, Via Orus 2, I-35129 Padua, Italy

[14] Univ Coll Dublin, Sch Publ Hlth Physiotherapy & Sports Sci, Inst Sport & Hlth, Dublin 4, Ireland

[15] Newcastle Univ, Human Nutr Res Ctr, Inst Cellular Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[16] Newcastle Univ, Inst Ageing, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[17] UK Ctr Integrated Res Musculoskeletal Ageing CIMA, MRC Arthrit Res, Newcastle Upon Tyne, Tyne & Wear, England

来源：

AGE AND AGEING | 2018年 / 47卷

基金：

英国惠康基金; 英国医学研究理事会; 英国生物技术与生命科学研究理事会;

关键词：

biomarkers; bone; cartilage; healthy ageing; musculoskeletal ageing; skeletal muscle; SKELETAL-MUSCLE MASS; BIOELECTRICAL-IMPEDANCE ANALYSIS; HORMONE REPLACEMENT THERAPY; OLIGOMERIC MATRIX PROTEIN; MESENCHYMAL STEM-CELLS; CHRONIC KIDNEY-DISEASE; BIOCHEMICAL MARKERS; OLDER-ADULTS; POSTMENOPAUSAL WOMEN; KNEE OSTEOARTHRITIS;

D O I：

10.1093/ageing/afy143

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The complexities and heterogeneity of the ageing process have slowed the development of consensus on appropriate biomarkers of healthy ageing. The Medical Research Council Arthritis Research UK Centre for Integrated research into Musculoskeletal Ageing (CIMA) is a collaboration between researchers and clinicians at the Universities of Liverpool, Sheffield and Newcastle. One of CIMA's objectives is to 'Identify and share optimal techniques and approaches to monitor age-related changes in all musculoskeletal tissues, and to provide an integrated assessment of musculoskeletal function' in other words to develop a toolkit for assessing musculoskeletal ageing. This toolkit is envisaged as an instrument that can be used to characterise and quantify musculoskeletal function during 'normal' ageing, lend itself to use in large-scale, internationally important cohorts, and provide a set of biomarker outcome measures for epidemiological and intervention studies designed to enhance healthy musculoskeletal ageing. Such potential biomarkers include: biochemical measurements in biofluids or tissue samples, in vivo measurements of body composition, imaging of structural and physical properties, and functional tests. This review assesses candidate biomarkers of musculoskeletal ageing under these four headings, details their biological bases, strengths and limitations, and makes practical recommendations for their use. In addition, we identify gaps in the evidence base and priorities for further research on biomarkers of musculoskeletal ageing.

引用

页码：iv1 / iv19

页数：19

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