Neutrophil-Lymphocyte Ratio Predicts Functional and Safety Outcomes after Endovascular Treatment for Acute Ischemic Stroke

被引：79

作者：

Duan, Zhenhui ^{[1
]}

Wang, Huaiming ^{[2
,3
]}

Wang, Zhen ^{[4
]}

Hao, Yonggang ^{[1
,5
]}

Zi, Wenjie ^{[2
]}

Yang, Dong ^{[2
]}

Zhou, Zhiming ^{[6
]}

Liu, Wenhua ^{[7
]}

Lin, Min ^{[8
]}

Shi, Zhonghua ^{[9
]}

Lv, Penghua ^{[10
]}

Wan, Yue ^{[11
]}

Xu, Gelin ^{[1
,2
]}

Xiong, Yunyun ^{[2
]}

Zhu, Wusheng ^{[1
,2
]}

Liu, Xinfeng ^{[1
,2
]}

机构：

[1] Southern Med Univ, Jinling Hosp, Dept Neurol, Nanjing, Jiangsu, Peoples R China

[2] Nanjing Univ, Jinling Hosp, Dept Neurol, Med Sch, 305 East Zhongshan Rd, Nanjing 210002, Jiangsu, Peoples R China

[3] 89th Hosp Peoples Liberat Army, Dept Neurol, Weifang, Peoples R China

[4] Changsha Cent Hosp, Dept Neurol, Changsha, Hunan, Peoples R China

[5] Soochow Univ, Affiliated Hosp 1, Dept Emergency Med, Suzhou, Peoples R China

[6] Wannan Med Coll, Yijishan Hosp, Dept Neurol, Wuhu, Peoples R China

[7] Wuhan 1 Hosp, Dept Neurol, Wuhan, Hubei, Peoples R China

[8] Fuzhou Gen Hosp Peoples Liberat Army, Dept Neurol, Fuzhou, Fujian, Peoples R China

[9] 101st Hosp Peoples Liberat Army, Dept Neurosurg, Wuxi, Peoples R China

[10] Northern Jiangsu Peoples Hosp, Dept Intervent Radiol, Yangzhou, Jiangsu, Peoples R China

[11] Hubei Zhongshan Hosp, Dept Neurol, Wuhan, Hubei, Peoples R China

来源：

CEREBROVASCULAR DISEASES | 2018年 / 45卷 / 5-6期

基金：

中国国家自然科学基金;

关键词：

Neutrophil-lymphocyte ratio; Endovascular treatment; Stroke; Outcome; ACUTE CEREBRAL INFARCTION; REGULATORY T-CELLS; THERAPY; THROMBECTOMY; RECOMMENDATIONS; CLASSIFICATION; INFLAMMATION; SUBTYPES; TRIAL;

D O I：

10.1159/000489401

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and Objective: Endovascular treatment (EVT) is proven to be safe and effective for treating acute large vessel occlusion stroke (LVOS). The neutrophil-lymphocyte ratio (NLR) reflects systemic inflammation, which plays an important role in the process of treating ischemic stroke. This study aims to explore the relationship between NLR and the clinical outcomes of LVOS patients undergoing EVT. Methods: Patients were selected from the EVT for acUte Anterior circuLation (ACTUAL) ischemic stroke registry. The laboratory data (neutrophil count, lymphocyte count) before EVT were collected. Poor functional outcome was defined as modified Rankin Scale (mRS) of 3-6 at 3 months. Multivariable logistic regression analyses were performed to explore the relationship of NLR with functional outcome, symptomatic intracranial hemorrhage (sICH), and mortality. Results: We eventually included 616 patients (median of age, 66 years; 40.3% female). There were 350 (56.7%) patients achieving mRS of 3-6 at 3 months, 98 (15.9%) patients with sICH, and the mortality at 3 months was 24.8% (153/616). Baseline NLR was independently associated with poor functional outcome (OR 1.58; 95% CI 1.02-2.45; p = 0.039) and sICH (OR 1.84; 95% CI 1.09-3.11; p = 0.023) but showed a trend for predicting 3-month mortality (OR 1.57; 95% CI 0.94-2.65; p = 0.088). Conclusions: NLR independently predicts 3-month functional outcome and sICH but the existence of a trend association with mortality after EVT for acute anterior circulation LVOS patients. (c) 2018 S. Karger AG, Basel

引用

页码：221 / 227

页数：7

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