Dopamine D3 receptor antagonists as therapeutic agents

被引：225

作者：

Joyce, JN ^{[1
]}

Milian, MJ ^{[1
]}

机构：

[1] Inst Rech Servier, Div Psychopharmacol, F-78290 Croissy Sur Seine, France

来源：

DRUG DISCOVERY TODAY | 2005年 / 10卷 / 13期

关键词：

D O I：

10.1016/S1359-6446(05)03491-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The behavioral and pathophysiological role of the dopamine D-3 receptor, which was deduced from anatomical, lesion and drug treatment studies in the ten years following cloning of the receptor, indicated that its functions differed from those of the D-2 receptor. There is increasingly strong evidence that D-3 receptor antagonists will be effective antipsychotic agents. In this regard, an amelioration of the negative and cognitive symptoms of schizophrenia holds the most promise for D-3 receptor antagonists, a concept currently under clinical evaluation. In addition, D-3 receptors could be involved in behavioral sensitization and the potential application of D-3 receptor antagonists in the treatment of drug abuse is undergoing intensive experimental investigation.

引用

页码：917 / 925

页数：9

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