Obesity and Atrial Fibrillation Prevalence, Pathogenesis, and Prognosis Effects of Weight Loss and Exercise

被引：351

作者：

Lavie, Carl J. ^{[1
]}

Pandey, Ambarish ^{[2
]}

Lau, Dennis H. ^{[3
,4
]}

Alpert, Martin A. ^{[5
]}

Sanders, Prashanthan ^{[3
,4
]}

机构：

[1] Univ Queensland, Dept Cardiovasc Dis, John Ochsner Heart & Vasc Inst, Ochsner Clin Sch,Sch Med, New Orleans, LA USA

[2] Univ Texas Southwestern Med Ctr Dallas, Div Cardiol, Dallas, TX 75390 USA

[3] Univ Adelaide, Ctr Heart Rhythm Disorders, South Australian Hlth & Med Res Inst, Adelaide, SA, Australia

[4] Royal Adelaide Hosp, Adelaide, SA, Australia

[5] Univ Missouri, Sch Med, Div Cardiovasc Med, Columbia, MO USA

来源：

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | 2017年 / 70卷 / 16期

基金：

英国医学研究理事会;

关键词：

cardiac arrhythmia; cardiovascular diseases; fat; fitness; heart rhythm; CROSS-COUNTRY SKIERS; BODY-MASS INDEX; PHYSICAL-ACTIVITY; HEART-FAILURE; RISK-FACTOR; FOLLOW-UP; CARDIORESPIRATORY FITNESS; ATHEROSCLEROSIS RISK; PERICARDIAL FAT; ADIPOSE-TISSUE;

D O I：

10.1016/j.jacc.2017.09.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Both obesity and atrial fibrillation (AF) are increasing in epidemic proportions, and both increase the prevalence of cardiovascular disease events. Obesity has adverse effects on cardiovascular hemodynamics and cardiac structure and function, and increases the prevalence of AF, partly related to electroanatomic remodeling in obese patients. However, numerous studies, including in AF, have demonstrated an obesity paradox, where overweight and obese patients with these disorders have a better prognosis than do leaner patients with the same degree of severity of cardiovascular disease/AF. In this paper, the authors discuss special issues regarding AF in obesity, as well as the evidence that despite the presence of an obesity paradox, there are benefits of weight loss, physical activity/exercise training, and increases in cardiorespiratory fitness on the prognosis of obese patients with AF. (C) 2017 by the American College of Cardiology Foundation.

引用

页码：2022 / 2035

页数：14

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