Emerging nanomedicine-based strategies for preventing metastasis of pancreatic cancer

被引：31
作者：
Li, Yong-Jiang [1 ,2 ,3 ]
Wu, Jun-Yong [1 ,2 ,3 ]
Wang, Jie-Min [1 ,2 ,3 ]
Xiang, Da-Xiong [1 ,2 ,3 ]
机构：
[1] Cent South Univ, Xiangya Hosp 2, Dept Pharm, Changsha 410011, Hunan, Peoples R China
[2] Cent South Univ, Inst Clin Pharm, Changsha 410011, Hunan, Peoples R China
[3] Hunan Prov Engn Res Ctr Translat Med AndInnovat D, Changsha, Hunan, Peoples R China
来源：
JOURNAL OF CONTROLLED RELEASE | 2020年 / 320卷
关键词：
Pancreatic cancer; Metastasis; Cancer stem cells; Tumor microenvironment; Circulating tumor cells; Exosomes; Nanomedicine; Nanotechnology; CIRCULATING TUMOR-CELLS; STEM-CELLS; MESENCHYMAL TRANSITION; EXOSOMES; NANOPARTICLES; GEMCITABINE; EXPRESSION; RESISTANCE; BARRIERS; EFFICACY;
D O I：
10.1016/j.jconrel.2020.01.041
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Pancreatic cancer is highly metastatic with very short survival and increasing mortality rates. Recent advances in therapeutic regimes and other adjuvant therapies improved slightly overall survival of pancreatic cancer, but fighting metastasis has been challenging and is necessary for achieving cure. Nanomedicine, not limited to drug delivery, offers opportunities for targeting cancer metastasis. Research regarding the prevention of metastasis of this malignancy is highly demanded. Herein, we focus on advances of nanomedicine-based strategies for targeting different stages of metastasis, including cancer stem cells, tumor microenvironment, circulating tumor cells and tumor exosomes. A greater emphasis on targeting metastasis of pancreatic cancer using nanomedicine-based strategies provides avenues for improving pancreatic cancer treatment outcomes in the future.
引用
收藏
页码：105 / 111
页数：7
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