B cells in glomerulonephritis: focus on lupus nephritis

被引：17

作者：

Clatworthy, Menna R.

Smith, Kenneth G. C.

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Dept Med, Div Renal Med, Cambridge CB2 2XY, England

[2] Univ Cambridge, Addenbrookes Hosp, Inst Med Res, Cambridge CB2 2XY, England

来源：

SEMINARS IN IMMUNOPATHOLOGY | 2007年 / 29卷 / 04期

关键词：

B cell; systemic lupus erythematosus; lupus nephritis; glomerulonephritis; autoimmunity; autoantibodies; immune complex; antigen presentation; tolerance;

D O I：

10.1007/s00281-007-0092-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The production of pathogenic antibody has been traditionally viewed as the principle contribution of B cells to the pathogenesis of immune-mediated glomerulonephritis. However, it is increasingly appreciated that B cells play a much broader role in such diseases, functioning as antigen-presenting cells, regulators of T cells, dendritic cells, and macrophages and orchestrators of local lymphatic expansion. In this review, we provide an overview of basic B cell biology and consider the evidence implicating B cells in one of the archetypal immune-mediated glomerulonephritides, lupus nephritis.

引用

页码：337 / 353

页数：17

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