Thyroid Hormone Transporters

被引：143

作者：

Groeneweg, Stefan ^{[1
]}

van Geest, Ferdy S. ^{[1
]}

Peeters, Robin P. ^{[1
]}

Heuer, Heike ^{[2
]}

Visser, W. Edward ^{[1
]}

机构：

[1] Erasmus MC, Netherlands Acad Ctr Thyroid Dis, Dept Internal Med, NL-3015 GD Rotterdam, Netherlands

[2] Univ Duisburg Essen, Univ Hosp Essen, Dept Endocrinol Diabet & Metab, D-45122 Essen, Germany

来源：

ENDOCRINE REVIEWS | 2020年 / 41卷 / 02期

关键词：

thyroid hormone; thyroid hormone transport; thyroid hormone transporters; MCT8; deficiency; Allan-Herndon-Dudley syndrome; AHDS; OATP1C1; AMINO-ACID TRANSPORTER; HERNDON-DUDLEY-SYNDROME; ORGANIC ANION TRANSPORTER; TAUROCHOLATE COTRANSPORTING POLYPEPTIDE; BLOOD-BRAIN-BARRIER; LINKED MENTAL-RETARDATION; TRANSMEMBRANE DOMAIN 6; CENTRAL-NERVOUS-SYSTEM; FETAL CEREBRAL-CORTEX; MONOCARBOXYLATE TRANSPORTER;

D O I：

10.1210/endrev/bnz008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Thyroid hormone transporters at the plasma membrane govern intracellular bioavailability of thyroid hormone. Monocarboxylate transporter (MCT) 8 and MCT10, organic anion transporting polypeptide (OATP) 1C1, and SLC17A4 are currently known as transporters displaying the highest specificity toward thyroid hormones. Structure-function studies using homology modeling and mutational screens have led to better understanding of the molecular basis of thyroid hormone transport. Mutations in MCT8 and in OATP1C1 have been associated with clinical disorders. Different animal models have provided insight into the functional role of thyroid hormone transporters, in particular MCT8. Different treatment strategies for MCT8 deficiency have been explored, of which thyroid hormone analogue therapy is currently applied in patients. Future studies may reveal the identity of as-yet-undiscovered thyroid hormone transporters. Complementary studies employing animal and human models will provide further insight into the role of transporters in health and disease. [GRAPHICS] .

引用

页码：146 / 201

页数：56

共 477 条

[71] Developmental expression of canalicular transporter genes in human liver [J].