Determination of phenol and o-cresol by GC/MS in a fatal poisoning case

被引：18

作者：

Boatto, G ^{[1
]}

Nieddu, M

Carta, A

Pau, A

Lorenzoni, S

Manconi, P

Serra, D

机构：

[1] Univ Sassari, Dipartimento Farm Chim Tossicol, I-07100 Sassari, Italy

[2] Presidio Osped Sassari, Unita Operat Patol Forense, Sassari, Italy

来源：

FORENSIC SCIENCE INTERNATIONAL | 2004年 / 139卷 / 2-3期

关键词：

phenol; cresol; gel permeation; SPE; GC/MS;

D O I：

10.1016/j.forsciint.2003.10.023

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

A fatality due to the ingestion of solution containing phenol and o-cresol is described. The pathological findings were typical of acute substantial poisoning. Blood, urine and stomach content were obtained during post mortem examinations. Phenol and o-cresol were identified using GC/MS. The extractions from autopsy materials were obtained as follows: by gel permeation with cyclohexane/dichloromethane from stomach content, by solid phase extraction (SPE) from urine and by deproteinization with acetonitrile from blood. The phenol and o-cresol concentrations in the samples were found, respectively, as follows: 115.0 and 5.0 mug/g in the stomach contents, 58.3 and 1.9 mug/ml in the blood, 3.3 and 20.5 mug/ml in the urine. Distributions of phenol in fatal poisonings have been reported [J. Forensic Sci. 27 (1982) 729; Forensic Sci. Int. 19 (1982) 177], but, usually, colorimetry was used as the analytical method and it cannot exclude the interference of other phenolic compounds. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：191 / 194

页数：4

共 10 条

[1]

Agency for Toxic Substances and Disease Registry (ATSDR), 1989, TOX PROF PHEN

[2] A RAPID GAS-CHROMATOGRAPHIC METHOD FOR THE DETERMINATION OF FREE PHENOL IN BLOOD [J].