Copper-Catalyzed Di- and Trifluoromethylation of α,β-Unsaturated Carboxylic Acids: A Protocol for Vinylic Fluoroalkylations

被引：228

作者：

He, Zhengbiao ^{[1
]}

Luo, Tao ^{[1
]}

Hu, Mingyou ^{[1
]}

Cao, Yanjing ^{[1
]}

Hu, Jinbo ^{[1
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 16期

基金：

中国国家自然科学基金;

关键词：

carboxylic acids; copper; fluorine; stereoselectivity; synthetic methods; NUCLEOPHILIC TRIFLUOROMETHYLATION; BORONIC ACIDS; REAGENT; FLUORINE; ETHERS; ARYL; (PHENYLSULFONYL)DIFLUOROMETHYLATION; PERFLUOROALKYLATION; ALKENES; SALTS;

D O I：

10.1002/anie.201200140

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dual action: The Lewis acid CuF 2·2 H 2O efficiently catalyzes the reaction between electrophilic fluoroalkylating agents and α,β-unsaturated carboxylic acids by dually activating both reactants, thus affording di- and trifluoromethyl alkenes in high yields with excellent E/Z selectivity. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：3944 / 3947

页数：4

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