Methyl Group in Isocopalane Derivative Showed an Unusual Negative 1H NMR Chemical Shift

被引：2

作者：

Xiao, Xiong ^{[1
]}

Chen, Tianqi ^{[1
]}

Zhang, Fengfeng ^{[1
]}

Cheng, Jiagao ^{[1
]}

Wu, Peiying ^{[3
]}

Ren, Jiangmeng ^{[1
]}

Zeng, Bubing ^{[1
,2
]}

机构：

[1] E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Sch Pharm, Shanghai 200237, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Synthet Chem Nat Subst, Shanghai 200032, Peoples R China

[3] Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai 201203, Peoples R China

来源：

CHINESE JOURNAL OF CHEMISTRY | 2015年 / 33卷 / 06期

基金：

中国国家自然科学基金;

关键词：

shielding effect; diterpenoid; dihydropyrazole; negative chemical shift; computational study; RING;

D O I：

10.1002/cjoc.201500187

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An unusual negative H-1 NMR chemical shift of methyl group was discovered in condensation product of isocopalane diterpenoid with p-toluenesulfonyl hydrazide. 2D NMR, computational studies and single-crystal X-ray diffraction analysis showed that the C-20 methyl group was shielded.

引用

页码：643 / 645

页数：3

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