Voriconazole serum concentrations in an infant treated for Trichosporon beigelii infection

被引：18

作者：

Maples, HD

Stowe, CD

Saccente, SL

Jacobs, RF

机构：

[1] Univ Arkansas Med Sci, Coll Pharm, Dept Pediat, Little Rock, AR 72205 USA

[2] Arkansas Childrens Hosp, Little Rock, AR 72202 USA

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2003年 / 22卷 / 11期

关键词：

voriconazole; skin infection; Trichosporon beigelii; infant;

D O I：

10.1097/01.inf.0000095167.38306.76

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A neutropenic 10-week-old with hemophagocytic lymphohistiocytosis developed a cutaneous Trichosporon beigelii infection that was treated for 78 days with voriconazole. A starting dose of 6 mg/kg/ dose every 12 h was initiated, and serum concentrations were obtained. The infection resolved; however, the serum concentrations obtained while receiving and not receiving phenobarbital would be considered subtherapeutic for the treatment of invasive fungal infection.

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收藏

页码：1022 / 1024

页数：3

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