Multifunctional mesoporous silica nanocomposite nanoparticles for pH controlled drug release and dual modal imaging

被引：65

作者：

Lee, Ji Eun ^{[1
,2
]}

Lee, Dong Jun ^{[1
,2
]}

Lee, Nohyun ^{[1
,2
]}

Kim, Byung Hyo ^{[1
,2
]}

Choi, Seung Hong ^{[3
,4
]}

Hyeon, Taeghwan ^{[1
,2
]}

机构：

[1] Seoul Natl Univ, Natl Creat Res Initiat, Ctr Oxide Nanocrystalline Mat, World Class Univ WCU Program Chem Convergence Ene, Seoul 151744, South Korea

[2] Seoul Natl Univ, Sch Chem & Biol Engn, Seoul 151744, South Korea

[3] Seoul Natl Univ Hosp, Seoul 110744, South Korea

[4] Seoul Natl Univ, Inst Radiat Med, Med Res Ctr, Seoul 110744, South Korea

来源：

JOURNAL OF MATERIALS CHEMISTRY | 2011年 / 21卷 / 42期

基金：

新加坡国家研究基金会;

关键词：

MAGNETIC NANOPARTICLES; DELIVERY; BIODISTRIBUTION; FABRICATION; NANOVALVES; ASSEMBLIES; MOLECULES; ENSEMBLES; THERAPY; SYSTEMS;

D O I：

10.1039/c1jm11869b

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Multifunctional nanocomposite nanoparticles for simultaneous fluorescence and magnetic resonance (MR) imaging, and pH-sensitive drug release were fabricated by immobilizing pH responsive hydrazone bonds, magnetite nanoparticles and fluorescent dyes in mesoporous silica nanoparticles. pH dependent release of doxorubicin was demonstrated and the nanocomposite nanoparticles show fluorescence emission and MR contrast effect.

引用

页码：16869 / 16872

页数：4

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