New Synthetic Methodology toward Macrolides/Macrolactams via Palladium-Catalyzed Carbon-Heteroatom Bond-Forming Reactions

被引：1

作者：

Sengoku, Tetsuya ^{[1
]}

Hamamatsu, Tomoya ^{[1
]}

Inuzuka, Toshiyasu ^{[2
]}

Takahashi, Masaki ^{[1
]}

Yoda, Hidemi ^{[1
]}

机构：

[1] Shizuoka Univ, Fac Engn, Dept Mat Sci, Naka Ku, Hamamatsu, Shizuoka 4328561, Japan

[2] Gifu Univ, Life Sci Res Ctr, Div Instrumental Anal, Gifu 5011193, Japan

来源：

SYNLETT | 2011年 / 12期

关键词：

macrolactones; macrolactams; palladium-catalyzed reaction; carbon-heteroatom bond formation; 2-METHYL-6-NITROBENZOIC ANHYDRIDE; MACROLIDES; OXIDATION; MACROLACTONIZATION; LACTONIZATION; ANTIBIOTICS; CYCLIZATION; EFFICIENT; ACIDS;

D O I：

10.1055/s-0030-1260812

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise and versatile syntheses of 11-16-membered macrolides and 13-15-membered macrolactams have been achieved using a Tsuji-Trost type reaction. This approach is composed of intramolecular cyclization employing ethyl carbonate with carboxylic acids and catalytic amount of Pd(PPh(3))(4) to form carbon-heteroatom covalent bonds with no use of stoichiometric reagents.

引用

页码：1766 / 1768

页数：3

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