Effect of dupilumab treatment in a severe asthma patient with EGPA

被引：11

作者：

Matucci, Andrea ^{[1
]}

Bormioli, Susanna ^{[1
]}

Bercich, Luisa ^{[2
]}

Comin, Camilla E. ^{[3
]}

Bezzi, Michela ^{[4
]}

Vivarelli, Emanuele ^{[1
]}

Vultaggio, Alessandra ^{[1
]}

机构：

[1] Univ Florence, Immunoallergol Unit, AOU Careggi, Florence, Italy

[2] ASST Spedali Civili Brescia, Dept Pathol, Brescia, Italy

[3] Univ Florence, Sect Surg Histopathol & Mol Pathol, Dept Expt & Clin Med, Florence, Italy

[4] ASST Spedali Civili Brescia, UOC Pneumol Endoscop Unit, Brescia, Italy

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE | 2021年 / 9卷 / 10期

关键词：

EOSINOPHILIC GRANULOMATOSIS; MEPOLIZUMAB;

D O I：

10.1016/j.jaip.2021.06.033

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Type 2 cytokines (IL-4, IL-5, and IL-13) have a key role in inflammatory processes in asthma and eosinophilic granulomatosis with polyangiitis, and biologic therapies are new therapeutic opportunities for patients with asthma and eosinophilic granulomatosis with polyangiitis. Airway remodeling may condition overall therapeutic response in severe asthmatic patients. Alterations of the airway wall may change over time, at least partly because of the effect of treatment. Anti-IL-4/IL-13 strategy is able to resolve goblet cell hyperplasia seen in severe asthmatic patients.

引用

页码：3824 / 3825

页数：2

共 7 条

[1] Epithelial tethering of MUC5AC-rich mucus impairs mucociliary transport in asthma [J].

Bonser, Luke R. ;

Zlock, Lorna ;

Finkbeiner, Walter ;

Erle, David J. .

JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (06) :2367-2371

[2] Dividing the Janus vasculitis? Pathophysiology of eosinophilic granulomatosis with polyangitis [J].

Chaigne, Benjamin ;

Terrier, Benjamin ;

Thieblemont, Nathalie ;

Witko-Sarsat, Veronique ;

Mouthon, Luc .

AUTOIMMUNITY REVIEWS, 2016, 15 (02) :139-145

[3] Respiratory manifestations of eosinophilic granulornatosis with polyanglitis (Churg-Strauss) [J].

Cottin, Vincent ;

Bel, Elisabeth ;

Bottero, Paolo ;

Dalhoff, Klaus ;

Humbert, Marc ;

Lazor, Romain ;

Sinico, Renato A. ;

Sivasothy, Pasupathy ;

Wechsler, Michael E. ;

Groh, Matthieu ;

Marchand-Adam, Sylvain ;

Khouatral, Chahera ;

Wallaert, Benoit ;

Taille, Camille ;

Delaval, Philippe ;

Cadranel, Jacques ;

Bonniaud, Philippe ;

Prevot, Gregoire ;

Hirschi, Sandrine ;

Gondouin, Anne ;

Dunogue, Bertrand ;

Chatte, Gerard ;

Briault, Amandine ;

Jayne, David ;

Guillevin, Loic ;

Cordier, Jean-Francois .

EUROPEAN RESPIRATORY JOURNAL, 2016, 48 (05) :1429-1441

[4] Targeting key proximal drivers of type 2 inflammation in disease [J].

Gandhi, Namita A. ;

Bennett, Brandy L. ;

Graham, Neil M. H. ;

Pirozzi, Gianluca ;

Stahl, Neil ;

Yancopoulos, George D. .

NATURE REVIEWS DRUG DISCOVERY, 2016, 15 (01) :35-50

[5] Eosinophilic Granulomatosis with Polyangiitis (Churg-Strauss) [J].

Nguyen, Yann ;

Guillevin, Loic .

SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 2018, 39 (04) :471-481

[6] Low-Dose Mepolizumab Effectiveness in Patients Suffering From Eosinophilic Granulomatosis With Polyangiitis [J].

Vultaggio, Alessandra ;

Nencini, Francesca ;

Bormioli, Susanna ;

Vivarelli, Emanuele ;

Dies, Laura ;

Rossi, Oliviero ;

Parronchi, Paola ;

Maggi, Enrico ;

Matucci, Andrea .

ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 2020, 12 (05) :885-893

[7] Mepolizumab or Placebo for Eosinophilic Granulomatosis with Polyangiitis [J].

Wechsler, M. E. ;

Akuthota, P. ;

Jayne, D. ;

Khoury, P. ;

Klion, A. ;

Langford, C. A. ;

Merkel, P. A. ;

Moosig, F. ;

Specks, U. ;

Cid, M. C. ;

Luqmani, R. ;

Brown, J. ;

Mallett, S. ;

Philipson, R. ;

Yancey, S. W. ;

Steinfeld, J. ;

Weller, P. F. ;

Gleich, G. J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2017, 376 (20) :1921-1932

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