Ceramide kinase kinase regulates the migration of bone marrow-derived mesenchymal stem cells

被引：12
作者：
Yu, Jinyeong [1 ]
Kim, Hye Min [2 ]
Kim, Kwang Pyo [2 ]
Son, Youngsook [1 ]
Kim, Min-Sik [2 ,3 ,4 ]
Park, Ki-Sook [3 ,5 ,6 ]
机构：
[1] Kyung Hee Univ, Grad Sch Biotechnol, Yongin 17104, South Korea
[2] Kyung Hee Univ, Dept Appl Chem, Yongin 17104, South Korea
[3] Kyung Hee Univ, Grad Sch, Dept Biomed Sci & Technol, Seoul 02447, South Korea
[4] DGIST, Dept New Biol, Daegu 42988, South Korea
[5] Kyung Hee Univ, East West Med Res Inst, Seoul 02447, South Korea
[6] Kyung Hee Univ, Med Ctr, Seoul 02447, South Korea
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2019年 / 508卷 / 02期
关键词：
Ceramide kinase; Mesenchymal stem cells; Migration; TGF-beta; N-cadherin; STROMAL CELLS; MEMBRANE; MOBILIZATION; INVOLVEMENT;
D O I：
10.1016/j.bbrc.2018.11.154
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Endogenous bone marrow-derived mesenchymal stem cells (BM-MSCs) are mobilized into peripheral blood and injured tissues by various growth factors and cytokines that are expressed in the injured tissues, such as substance P (SP), stromal cell derived factor-1 (SDF-1), and transforming growth factor-beta (TGF-beta). Extracellular bioactive lipid metabolites such as ceramide-1-phosphate and sphingosine-1-phosphate also modulate BM-MSC migration as SP, SDF-1, and TGF-beta. However, the roles of intrinsic lipid kinases of BM-MSCs in the stem cell migration are unclear. Here, we demonstrated that ceramide kinase mediates the chemotactic migration of BM-MSCs in response to SP, SDF-1, or TGF-beta. Furthermore, a specific inhibitor of ceramide kinase inhibited TGF-beta-induced migration of BM-MSCs and N-cadherin that is necessary for BM-MSCs migration in response to TGF-beta. Therefore, these results suggest that the intracellular ceramide kinase is required for the BM-MSCs migration and the roles of the intrinsic ceramide kinase in the migration are associated with N-cadherin regulation. (C) 2018 Published by Elsevier Inc.
引用
收藏
页码：361 / 367
页数：7
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