Long-term outcomes of laparoscopic versus open liver resection for hepatocellular carcinoma: Retrospective case -matched study

Background: Only few studies compared laparoscopic to open liver resection regarding degree of liver injury, in flammatory response and long-term outcomes. The aim of this study was to compare peri- operative and long-term outcomes between these two procedures in patients with hepatocellular carcinoma. Material and methods: Laparoscopic cases were retrospectively matched to open cases. Peri-operative and long-term outcomes were compared. Results: Twenty-seven patients in laparoscopic group were matched to 27 patients in open group. On the first postoperative day, white blood cell count, serum AST and serum ALT in laparoscopic group were signi ficantly lower than open group. Median follow up time was 58.07 months. The 1-, 3- and 5-year disease free survival and overall survival were not signi ficantly different between laparoscopic and open group. Conclusions: Laparoscopic liver resection in patients with hepatocellular carcinoma has potentially lesser degree of postoperative in flammatory response and liver injury, but similar survival outcomes compared to open liver resection. (C) 2020 The Author(s). Published by Elsevier Ltd on behalf of Surgical Associates Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).