An Allosteric Switch Primes Sequence-Specific DNA Recognition

被引：4
|
作者：
Walker, Matthew J. [1 ]
Varani, Gabriele [1 ]
机构：
[1] Univ Washington, Dept Chem, Seattle, WA 98195 USA
来源：
CELL | 2019年 / 176卷 / 1-2期
关键词：
PRIMASE;
D O I：
10.1016/j.cell.2018.12.020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Regulation of protein-DNA binding specificity occurs through myriad mechanisms. Boudet et al. discover yet a new form of specificity through allosteric regulation, an ATP-induced structural switch that mediates specific DNA recognition in an archaeoeukaryotic primase.
引用
收藏
页码：4 / 6
页数：4
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