An Allosteric Switch Primes Sequence-Specific DNA Recognition

被引：4
作者：
Walker, Matthew J. [1 ]
Varani, Gabriele [1 ]
机构：
[1] Univ Washington, Dept Chem, Seattle, WA 98195 USA
来源：
CELL | 2019年 / 176卷 / 1-2期
关键词：
PRIMASE;
D O I：
10.1016/j.cell.2018.12.020
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Regulation of protein-DNA binding specificity occurs through myriad mechanisms. Boudet et al. discover yet a new form of specificity through allosteric regulation, an ATP-induced structural switch that mediates specific DNA recognition in an archaeoeukaryotic primase.
引用
收藏
页码：4 / 6
页数：4
相关论文
共 10 条
  • [1] Mechanism of Concerted RNA-DNA Primer Synthesis by the Human Primosome
    Baranovskiy, Andrey G.
    Babayeva, Nigar D.
    Zhang, Yinbo
    Gu, Jianyou
    Suwa, Yoshiaki
    Pavlov, Youri I.
    Tahirov, Tahir H.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (19) : 10006 - 10020
  • [2] Properties of an unusual DNA primase from an archaeal plasmid
    Beck, Kirsten
    Lipps, Georg
    [J]. NUCLEIC ACIDS RESEARCH, 2007, 35 (17) : 5635 - 5645
  • [3] The archaeo-eukaryotic primase of plasmid pRN1 requires a helix bundle domain for faithful primer synthesis
    Beck, Kirsten
    Vannini, Alessandro
    Cramer, Patrick
    Lipps, Georg
    [J]. NUCLEIC ACIDS RESEARCH, 2010, 38 (19) : 6707 - 6718
  • [4] A Small Helical Bundle Prepares Primer Synthesis by Binding Two Nucleotides that Enhance Sequence-Specific Recognition of the DNA Template
    Boudet, Julien
    Devillier, Jean-Christophe
    Wiegand, Thomas
    Salmon, Loic
    Meier, Beat H.
    Lipps, Georg
    Allain, Frederic H. -T.
    [J]. CELL, 2019, 176 (1-2) : 154 - +
  • [5] Structures to complement the archaeo-eukaryotic primases catalytic cycle description: What's next?
    Boudet, Julien
    Devillier, Jean-Christophe
    Allain, Frederic H. -T.
    Lipps, Georg
    [J]. COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2015, 13 : 339 - 351
  • [6] DAVEY SK, 1990, J BIOL CHEM, V265, P3611
  • [7] Interaction of ribonucleoside triphosphates with the gene 4 primase of bacteriophage T7
    Frick, DN
    Kumar, S
    Richardson, CC
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (50) : 35899 - 35907
  • [8] Mechanism and evolution of DNA primases
    Kuchta, Robert D.
    Stengel, Gudrun
    [J]. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2010, 1804 (05): : 1180 - 1189
  • [9] Protein-DNA binding: complexities and multi-protein codes
    Siggers, Trevor
    Gordan, Raluca
    [J]. NUCLEIC ACIDS RESEARCH, 2014, 42 (04) : 2099 - 2111
  • [10] Non-DNA-binding cofactors enhance DNA-binding specificity of a transcriptional regulatory complex
    Siggers, Trevor
    Duyzend, Michael H.
    Reddy, Jessica
    Khan, Sidra
    Bulyk, Martha L.
    [J]. MOLECULAR SYSTEMS BIOLOGY, 2011, 7
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