Limited polymorphism in the dihydropteroate synthetase gene (dhps) of Plasmodium vivax isolates from Thailand

被引：66

作者：

Imwong, M

Pukrittayakamee, S

Cheng, Q

Moore, C

Looareesuwan, S

Snounou, G

White, NJ

Day, NPJ

机构：

[1] Mahidol Univ, Fac Trop Med, Dept Clin Trop Med, Bangkok 10400, Thailand

[2] Australian Army Malaria Inst, Drug Resistance & Diagnost Dept, Brisbane, Qld, Australia

[3] Churchill Hosp, Ctr Clin Vaccinol & Trop Med, Oxford OX3 7LJ, England

[4] Inst Pasteur, Unite Parasitol Biomed, CNRS, URA 2581, Paris, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2005年 / 49卷 / 10期

关键词：

D O I：

10.1128/AAC.49.10.4393-4395.2005

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The dhps sequences of 55 Plasmodium vivax isolates (39 from Thailand and 16 from elsewhere) revealed mutant Pvdhps at codons 383 and/or 553 (A -> G) in 33 isolates, all from Thailand. Mutations of Pvdhps and Pvdhfr were correlated. Multiple mutations were associated with high-grade sulfadoxine-pyrimethamine resistance.

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页码：4393 / 4395

页数：3

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