Disappearing Polymorphs Revisited

被引：319

作者：

Bucar, Dejan-Kresimir ^{[1
]}

Lancaster, Robert W. ^{[1
]}

Bernstein, Joel ^{[2
,3
,4
]}

机构：

[1] UCL, Dept Chem, London WC1H 0AJ, England

[2] New York Univ Abu Dhabi, Fac Nat Sci, Abu Dhabi, U Arab Emirates

[3] New York Univ Shanghai, Pudong New Area, Shanghai 200122, Peoples R China

[4] Ben Gurion Univ Negev, Dept Chem, IL-84120 Beer Sheva, Israel

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2015年 / 54卷 / 24期

关键词：

crystallization; drug formulation; nucleation; polymorphism; solid-state chemistry; CRYSTAL-STRUCTURE PREDICTION; SMALL ORGANIC-MOLECULES; SOLID-STATE; PHARMACEUTICAL COCRYSTALS; LUMINESCENT PROPERTIES; CO-CRYSTALS; RANITIDINE HYDROCHLORIDE; ELECTRONIC-STRUCTURE; BLIND TEST; ACID;

D O I：

10.1002/anie.201410356

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Nearly twenty years ago, Dunitz and Bernstein described a selection of intriguing cases of polymorphs that disappear. The inability to obtain a crystal form that has previously been prepared is indeed a frustrating and potentially serious problem for solid-state scientists. This Review discusses recent occurrences and examples of disappearing polymorphs (as well as the emergence of elusive crystal forms) to demonstrate the enduring relevance of this troublesome, but always captivating, phenomenon in solid-state research. A number of these instances have been central issues in patent litigations. This Review, therefore, also highlights the complex relationship between crystal chemistry and the law.

引用

页码：6972 / 6993

页数：22

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