Active modulation in neat carbon dioxide packed column comprehensive two-dimensional supercritical fluid chromatography

被引：9

作者：

Petkovic, Orjen ^{[1
,2
]}

Guibal, Pierre ^{[1
,3
]}

Sassiat, Patrick ^{[1
]}

Vial, Jerome ^{[1
]}

Thiebaut, Didier ^{[1
]}

机构：

[1] PSL Res Univ, ESPCI Paris, CNRS ESPCI Paris, UMR CBI 8231,Lab Sci Analyt Bioanalyt & Miniaturi, 10 Rue Vauquelin, F-75231 Paris 5, France

[2] UNIRI, Sch Med, Dept Chem & Biochem, Brace Branchetta 21, Rijeta, Croatia

[3] SANOFI, Biopharmaceut Dev BioAnalyt, 13 Quai Jules Guesde, F-94400 Vitry Sur Seine, France

来源：

JOURNAL OF CHROMATOGRAPHY A | 2018年 / 1536卷

关键词：

Supercritical fluid chromatography; Comprehensive 2D SFC; Modulation; PHASE LIQUID-CHROMATOGRAPHY; GAS-CHROMATOGRAPHY; OIL; PETROLEUM;

D O I：

10.1016/j.chroma.2017.08.063

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

After demonstrating in a first paper the feasibility of SFCxSFC without decompression of the mobile phase, a modified interface has been developed in order to perform active modulation between the two SFC dimensions. In this paper, it is shown that the new interface enabled independent control of modulation parameters in SFCxSFC and performed a band compression effect of solutes between the two SFC dimensions. The effectiveness of this new modulation process was studied using a Design of Experiments. The SFCxSFC prototype was applied to the analysis of a real oil sample to demonstrate the benefits of the active modulator; in comparison to our previous results obtained without active modulation, better separation was obtained with the new interface owing to the peak compression occurring in the modulator. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：176 / 184

页数：9

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