Two-Step Synthesis of Polysubstituted 6-Nitroindoles under Flow Chemical and Microwave Conditions

被引：10

作者：

Sampaolesi, Susanna ^{[1
]}

Gabrielli, Serena ^{[1
]}

Ballini, Roberto ^{[1
]}

Palmieri, Alessandro ^{[1
]}

机构：

[1] Univ Camerino, Div Chem, Sch Sci & Technol, Green Chem Grp, Via S Agostino 1, I-62032 Camerino, MC, Italy

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2017年 / 359卷 / 19期

关键词：

domino reactions; flow chemistry; heterocycles; microwaves; nitro compounds; ONE-POT SYNTHESIS; BETA-NITROACRYLATES; SUBSTITUTED INDOLES; RING; NITRATION; NITROINDOLES; DERIVATIVES; ANTAGONISTS; DISCOVERY; PYRROLES;

D O I：

10.1002/adsc.201700790

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new simple and efficient synthesis of 6-nitroindoles, starting from N-carboxylalkylpyrrole-2-carboxaldehydes and protected beta-nitro ketones, has been developed. The method involves two distinct domino processes, respectively performed under flow chemical conditions and microwave irradiation. 6-Nitroindoles were produced in good to excellent overall yields.

引用

页码：3407 / 3413

页数：7

共 40 条

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