Two-Step Synthesis of Polysubstituted 6-Nitroindoles under Flow Chemical and Microwave Conditions

被引：10
|
作者：
Sampaolesi, Susanna [1 ]
Gabrielli, Serena [1 ]
Ballini, Roberto [1 ]
Palmieri, Alessandro [1 ]
机构：
[1] Univ Camerino, Div Chem, Sch Sci & Technol, Green Chem Grp, Via S Agostino 1, I-62032 Camerino, MC, Italy
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2017年 / 359卷 / 19期
关键词：
domino reactions; flow chemistry; heterocycles; microwaves; nitro compounds; ONE-POT SYNTHESIS; BETA-NITROACRYLATES; SUBSTITUTED INDOLES; RING; NITRATION; NITROINDOLES; DERIVATIVES; ANTAGONISTS; DISCOVERY; PYRROLES;
D O I：
10.1002/adsc.201700790
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new simple and efficient synthesis of 6-nitroindoles, starting from N-carboxylalkylpyrrole-2-carboxaldehydes and protected beta-nitro ketones, has been developed. The method involves two distinct domino processes, respectively performed under flow chemical conditions and microwave irradiation. 6-Nitroindoles were produced in good to excellent overall yields.
引用
收藏
页码：3407 / 3413
页数：7
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