Layer-specific cholinergic control of human and mouse cortical synaptic plasticity

被引：59

作者：

Verhoog, Matthijs B. ^{[1
]}

Obermayer, Joshua ^{[1
]}

Kortleven, Christian A. ^{[1
]}

Wilbers, Rene ^{[1
]}

Wester, Jordi ^{[1
]}

Baayen, Johannes C. ^{[2
]}

De Kock, Christiaan P. J. ^{[1
]}

Meredith, Rhiannon M. ^{[1
]}

Mansvelder, Huibert D. ^{[1
]}

机构：

[1] Vrije Univ Amsterdam, Ctr Neurogen & Cognit Res, Dept Integrat Neurophysiol, De Boelelaan 1085, NL-1081 HV Amsterdam, Netherlands

[2] VU Univ Med Ctr Amsterdam, Dept Neurosurg, Neurosci Campus Amsterdam,De Boelelaan 1117, NL-1081 HV Amsterdam, Netherlands

来源：

NATURE COMMUNICATIONS | 2016年 / 7卷

基金：

欧盟第七框架计划;

关键词：

NICOTINIC ACETYLCHOLINE-RECEPTORS; TIMING-DEPENDENT PLASTICITY; LONG-TERM POTENTIATION; HUMAN CEREBRAL-CORTEX; PREFRONTAL CORTEX; CA2+ PERMEABILITY; TRANSGENIC MICE; BINDING-SITES; NEURONS; RAT;

D O I：

10.1038/ncomms12826

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Individual cortical layers have distinct roles in information processing. All layers receive cholinergic inputs from the basal forebrain (BF), which is crucial for cognition. Acetylcholinergic receptors are differentially distributed across cortical layers, and recent evidence suggests that different populations of BF cholinergic neurons may target specific prefrontal cortical (PFC) layers, raising the question of whether cholinergic control of the PFC is layer dependent. Here we address this issue and reveal dendritic mechanisms by which endogenous cholinergic modulation of synaptic plasticity is opposite in superficial and deep layers of both mouse and human neocortex. Our results show that in different cortical layers, spike timing-dependent plasticity is oppositely regulated by the activation of nicotinic acetylcholine receptors (nAChRs) either located on dendrites of principal neurons or on GABAergic interneurons. Thus, layer-specific nAChR expression allows functional layer-specific control of cortical processing and plasticity by the BF cholinergic system, which is evolutionarily conserved from mice to humans.

引用

页数：13

共 69 条

[41] Dendritic and Axonal Architecture of Individual Pyramidal Neurons across Layers of Adult Human Neocortex [J].