Metastasis-associated long noncoding RNAs in gastrointestinal cancer: Implications for novel biomarkers and therapeutic targets

被引：8

作者：

Zhang, Fei-Fei ^{[1
]}

Luo, Yu-Hao ^{[1
]}

Wang, Hui ^{[2
]}

Zhao, Liang ^{[1
,3
]}

机构：

[1] Southern Med Univ, Nanfang Hosp, Dept Pathol, 1838 Guangzhoudadao South Rd, Guangzhou 510000, Guangdong, Peoples R China

[2] Guangzhou Med Univ, Affiliated Tumor Hosp, Dept Med Oncol, Guangzhou 510000, Guangdong, Peoples R China

[3] Southern Med Univ, Sch Basic Med Sci, Dept Pathol, Guangzhou 510000, Guangdong, Peoples R China

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2016年 / 22卷 / 39期

基金：

中国国家自然科学基金;

关键词：

Gastrointestinal cancer; Tumor metastasis; Long noncoding RNAs; Epithelial-to-mesenchymal transition; MicroRNAs; SQUAMOUS-CELL CARCINOMA; EPITHELIAL-MESENCHYMAL TRANSITION; PROMOTES TUMOR-GROWTH; POOR-PROGNOSIS; COLORECTAL-CANCER; GASTRIC-CANCER; MALAT1; PROMOTES; UP-REGULATION; DECREASED EXPRESSION; ANTISENSE RNA;

D O I：

10.3748/wjg.v22.i39.8735

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Long non-coding RNAs (lncRNAs), a newly discovered class of ncRNA molecules, have been widely accepted as crucial regulators of various diseases including cancer. Increasing numbers of studies have demonstrated that lncRNAs are involved in diverse physiological and pathophysiological processes, such as cell cycle progression, chromatin remodeling, gene transcription, and posttranscriptional processing. Aberrant expression of lncRNAs frequently occurs in gastrointestinal cancer and plays emerging roles in cancer metastasis. In this review, we focus on and outline the regulatory functions of recently identified metastasis-associated lncRNAs, and evaluate the potential roles of lncRNAs as novel diagnostic biomarkers and therapeutic targets in gastrointestinal cancer.

引用

页码：8735 / 8749

页数：15

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