Highly efficient and versatile synthesis of α,α-difluoro-γ-lactams via aminodifluoroalkylation of alkenes

被引：46

作者：

Chen, Hongtai ^{[1
]}

Wang, Xiaoyang ^{[1
]}

Guo, Minjie ^{[2
]}

Zhao, Wentao ^{[1
]}

Tang, Xiangyang ^{[1
]}

Wang, Guangwei ^{[1
,3
]}

机构：

[1] Tianjin Univ, Sch Sci, Dept Chem, Tianjin 300072, Peoples R China

[2] Tianjin Univ, Sch Pharmaceut Sci & Technol, Inst Mol Design & Synth, Tianjin 300072, Peoples R China

[3] Tianjin Key Lab Mol Optoelect Sci, Tianjin 300072, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2017年 / 4卷 / 12期

关键词：

GAMMA-LACTAMS; INTRAMOLECULAR HYDROAMINATION; UNACTIVATED ALKENES; H FUNCTIONALIZATION; MEDICINAL CHEMISTRY; PART; BOND; AMINOTRIFLUOROMETHYLATION; CATALYSIS; FLUORINE;

D O I：

10.1039/c7qo00611j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel method for the synthesis of alpha,alpha-difluoro-gamma-lactam derivatives has been developed using a copper/amine catalyst via a tandem radical cyclization pathway. This protocol provides a convenient and straightforward strategy for the rapid construction of various 3,3-difluoro-gamma-lactam moieties from easily available alkenes and N-aryl bromodifluoroacetamide as starting materials under mild reaction conditions.

引用

页码：2403 / 2407

页数：5

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