Highly efficient and versatile synthesis of α,α-difluoro-γ-lactams via aminodifluoroalkylation of alkenes

被引：44
作者：
Chen, Hongtai [1 ]
Wang, Xiaoyang [1 ]
Guo, Minjie [2 ]
Zhao, Wentao [1 ]
Tang, Xiangyang [1 ]
Wang, Guangwei [1 ,3 ]
机构：
[1] Tianjin Univ, Sch Sci, Dept Chem, Tianjin 300072, Peoples R China
[2] Tianjin Univ, Sch Pharmaceut Sci & Technol, Inst Mol Design & Synth, Tianjin 300072, Peoples R China
[3] Tianjin Key Lab Mol Optoelect Sci, Tianjin 300072, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2017年 / 4卷 / 12期
关键词：
GAMMA-LACTAMS; INTRAMOLECULAR HYDROAMINATION; UNACTIVATED ALKENES; H FUNCTIONALIZATION; MEDICINAL CHEMISTRY; PART; BOND; AMINOTRIFLUOROMETHYLATION; CATALYSIS; FLUORINE;
D O I：
10.1039/c7qo00611j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel method for the synthesis of alpha,alpha-difluoro-gamma-lactam derivatives has been developed using a copper/amine catalyst via a tandem radical cyclization pathway. This protocol provides a convenient and straightforward strategy for the rapid construction of various 3,3-difluoro-gamma-lactam moieties from easily available alkenes and N-aryl bromodifluoroacetamide as starting materials under mild reaction conditions.
引用
收藏
页码：2403 / 2407
页数：5
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