Synthesis and biological activities of potential metabolites of the non-nucleoside reverse transcriptase inhibitor efavirenz

被引：12

作者：

Markwalder, JA ^{[1
]}

Mutlib, DDCA ^{[1
]}

Cordova, BC ^{[1
]}

Klabe, RM ^{[1
]}

Seitz, SP ^{[1
]}

机构：

[1] DuPont Pharmaceut Co, Expt Stn, Wilmington, DE 19880 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 05期

关键词：

D O I：

10.1016/S0960-894X(01)00012-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Studies on the biotransformation of the clinically important non-nucleoside reverse transcriptase inhibitor efavirenz have shown that oxidation and secondary conjugation are important components of the processing of this molecule in vivo. We have synthesized metabolites of efavirenz to confirm their structure and to evaluate their activity as antivirals. (C) 2001 DuPont Pharmaceuticals Company. Published by Elsevier Science Ltd. All rights reserved.

引用

页码：619 / 622

页数：4

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