The diagnostic significance of serum alcohol dehydrogenase isoenzymes and aldehyde dehydrogenase activity in renal cell cancer patients

被引：7

作者：

Orywal, Karolina ^{[1
]}

Jelski, Wojciech ^{[1
]}

Werel, Tadeusz ^{[2
]}

Szmitkowski, Maciej ^{[1
]}

机构：

[1] Med Univ Bialystok, Dept Biochem Diagnost, Waszyngtona 15 A, PL-15276 Bialystok, Poland

[2] Med Univ, Dept Urol, Bialystok, Poland

来源：

EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2016年 / 100卷 / 03期

关键词：

Alcohol dehydrogenase isoenzymes; Aldehyde dehydrogenase; Renal cell carcinoma; Cancer markers; Diagnostic utility; CLASS-III; CLASS-I; EXPRESSION PROFILES; TUMOR-MARKERS; CARCINOMA; IDENTIFICATION; METABOLISM; ISOZYMES; ENZYMES; TISSUES;

D O I：

10.1016/j.yexmp.2016.04.001

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objectives: In previous experiments, we have found an increased level of class I ADH and total ADH activity in RCC tissues. Changes in cancer cells may be reflected by ADH activity in the serum and could thus be helpful for diagnostics of renal cancer. The aim of this study was to investigate a potential role of ADH and ALDH as tumor markers for RCC. Material and methods: Serum samples were taken from 59 patients with RCC and 52 healthy subjects. Class III and IV of ADH and total ADH activity was measured by the photometric method. For measurement of class I and II ADH and ALDH activity, we employed the fluorometric method. Results: The total activity of ADH and ADH I was significantly higher in the serum of patients with every stage of RCC compared to healthy subjects. The diagnostics criteria was higher for ADH I than for total ADH activity. The diagnostic sensitivity for ADH I was 73.36%, specificity 85.61%, predictive values of positive and negative results were 79.12 and 75.03% respectively. Area under ROC curve for ADH I was 0.748 and for total ADH 0.689. Conclusion: The results suggest a potential role of ADH I as a marker for RCC. (C) 2016 Elsevier Inc. All rights reserved.

引用

页码：416 / 420

页数：5

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