Cell cyclins: triggering elements of cancer or not?

被引：56
作者：
Stamatakos, Michael [1 ]
Palla, Victoria [1 ]
Karaiskos, Ioannis [2 ]
Xiromeritis, Konstantinos [3 ]
Alexiou, Ioannis [4 ]
Pateras, Ioannis [2 ]
Kontzoglou, Konstantinos [4 ]
机构：
[1] Univ Athens, Sch Med, Attikon Gen Hosp, Dept Surg 4, GR-11527 Athens, Greece
[2] Univ Athens, Sch Med, Laikon Gen Hosp, Dept Surg 1, GR-11527 Athens, Greece
[3] Univ Athens, Sch Med, Attikon Gen Hosp, Dept Vasc Surg, GR-11527 Athens, Greece
[4] Univ Athens, Sch Med, Laiko Gen Hosp, Dept Propaedeut Surg 2, GR-11527 Athens, Greece
来源：
WORLD JOURNAL OF SURGICAL ONCOLOGY | 2010年 / 8卷
关键词：
BREAST-CANCER; GENE AMPLIFICATION; DEPENDENT KINASE; OVARIAN-CANCER; D1; EXPRESSION; DNA-SYNTHESIS; OVEREXPRESSION; ACTIVATION; CDK2; PHOSPHORYLATION;
D O I：
10.1186/1477-7819-8-111
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cyclins are indispensable elements of the cell cycle and derangement of their function can lead to cancer formation. Recent studies have also revealed more mechanisms through which cyclins can express their oncogenic potential. This review focuses on the aberrant expression of G1/S cyclins and especially cyclin D and cyclin E; the pathways through which they lead to tumour formation and their involvement in different types of cancer. These elements indicate the mechanisms that could act as targets for cancer therapy.
引用
收藏
页数：8
相关论文
共 57 条
  • [51] Van Dross R, 2006, CELL CYCLE, V5, P472
  • [52] Cyclin D1 as a universally expressed mantle cell lymphoma-associated tumor antigen for immunotherapy
    Wang, M.
    Sun, L.
    Qian, J.
    Han, X.
    Zhang, L.
    Lin, P.
    Cai, Z.
    Yi, Q.
    [J]. LEUKEMIA, 2009, 23 (07) : 1320 - 1328
  • [53] Low molecular weight cyclin E is specific in breast cancer and is associated with mechanisms of tumor progression
    Wingate, Hannah
    Puskas, Agnes
    Duong, Mylinh
    Bui, Tuyen
    Richardson, Dana
    Liu, Yanna
    Tucker, Susan L.
    Van Pelt, Carolyn
    Meijer, Laurent
    Hunt, Kelly
    Keyomarsi, Khandan
    [J]. CELL CYCLE, 2009, 8 (07) : 1062 - 1068
  • [54] Antisense to cyclin D1 inhibits vascular endothelial growth factor-stimulated growth of vascular endothelial cells: Implication of tumor vascularization
    Yasui, Masayoshi
    Yamamoto, Hirofumi
    Ngan, Chew Yee
    Damdinsuren, Bazarragchaa
    Sugita, Yurika
    Fukunaga, Hiroki
    Gu, Jinyu
    Maeda, Makiko
    Takemasa, Ichiro
    Ikeda, Masataka
    Fujio, Yasushi
    Sekimoto, Mitsugu
    Matsuura, Nariaki
    Weinstein, I. Bernard
    Monden, Morito
    [J]. CLINICAL CANCER RESEARCH, 2006, 12 (15) : 4720 - 4729
  • [55] Yasui W, 1996, J Exp Ther Oncol, V1, P88
  • [56] Yasui W, 1996, VIRCHOWS ARCH, V429, P13
  • [57] Cyclin D1/Cyclin-Dependent Kinase 4 Interacts with Filamin A and Affects the Migration and Invasion Potential of Breast Cancer Cells
    Zhong, Zhijiu
    Yeow, Wen-Shuz
    Zou, Chunhua
    Wassell, Richard
    Wang, Chenguang
    Pestell, Richard G.
    Quong, Judy N.
    Quong, Andrew A.
    [J]. CANCER RESEARCH, 2010, 70 (05) : 2105 - 2114
123456