Cell cyclins: triggering elements of cancer or not?

被引：57

作者：

Stamatakos, Michael ^{[1
]}

Palla, Victoria ^{[1
]}

Karaiskos, Ioannis ^{[2
]}

Xiromeritis, Konstantinos ^{[3
]}

Alexiou, Ioannis ^{[4
]}

Pateras, Ioannis ^{[2
]}

Kontzoglou, Konstantinos ^{[4
]}

机构：

[1] Univ Athens, Sch Med, Attikon Gen Hosp, Dept Surg 4, GR-11527 Athens, Greece

[2] Univ Athens, Sch Med, Laikon Gen Hosp, Dept Surg 1, GR-11527 Athens, Greece

[3] Univ Athens, Sch Med, Attikon Gen Hosp, Dept Vasc Surg, GR-11527 Athens, Greece

[4] Univ Athens, Sch Med, Laiko Gen Hosp, Dept Propaedeut Surg 2, GR-11527 Athens, Greece

来源：

WORLD JOURNAL OF SURGICAL ONCOLOGY | 2010年 / 8卷

关键词：

BREAST-CANCER; GENE AMPLIFICATION; DEPENDENT KINASE; OVARIAN-CANCER; D1; EXPRESSION; DNA-SYNTHESIS; OVEREXPRESSION; ACTIVATION; CDK2; PHOSPHORYLATION;

D O I：

10.1186/1477-7819-8-111

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cyclins are indispensable elements of the cell cycle and derangement of their function can lead to cancer formation. Recent studies have also revealed more mechanisms through which cyclins can express their oncogenic potential. This review focuses on the aberrant expression of G1/S cyclins and especially cyclin D and cyclin E; the pathways through which they lead to tumour formation and their involvement in different types of cancer. These elements indicate the mechanisms that could act as targets for cancer therapy.

引用

页数：8

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