Cell cyclins: triggering elements of cancer or not?

被引：56
作者：
Stamatakos, Michael [1 ]
Palla, Victoria [1 ]
Karaiskos, Ioannis [2 ]
Xiromeritis, Konstantinos [3 ]
Alexiou, Ioannis [4 ]
Pateras, Ioannis [2 ]
Kontzoglou, Konstantinos [4 ]
机构：
[1] Univ Athens, Sch Med, Attikon Gen Hosp, Dept Surg 4, GR-11527 Athens, Greece
[2] Univ Athens, Sch Med, Laikon Gen Hosp, Dept Surg 1, GR-11527 Athens, Greece
[3] Univ Athens, Sch Med, Attikon Gen Hosp, Dept Vasc Surg, GR-11527 Athens, Greece
[4] Univ Athens, Sch Med, Laiko Gen Hosp, Dept Propaedeut Surg 2, GR-11527 Athens, Greece
来源：
WORLD JOURNAL OF SURGICAL ONCOLOGY | 2010年 / 8卷
关键词：
BREAST-CANCER; GENE AMPLIFICATION; DEPENDENT KINASE; OVARIAN-CANCER; D1; EXPRESSION; DNA-SYNTHESIS; OVEREXPRESSION; ACTIVATION; CDK2; PHOSPHORYLATION;
D O I：
10.1186/1477-7819-8-111
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cyclins are indispensable elements of the cell cycle and derangement of their function can lead to cancer formation. Recent studies have also revealed more mechanisms through which cyclins can express their oncogenic potential. This review focuses on the aberrant expression of G1/S cyclins and especially cyclin D and cyclin E; the pathways through which they lead to tumour formation and their involvement in different types of cancer. These elements indicate the mechanisms that could act as targets for cancer therapy.
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页数：8
相关论文
共 57 条
  • [1] Cyclin D1 expression in typical chronic lymphocytic leukaemia
    Abboudi, Zaid
    Patel, Ketan
    Naresh, Kikkeri N.
    [J]. EUROPEAN JOURNAL OF HAEMATOLOGY, 2009, 83 (03) : 203 - 207
  • [2] The cyclin D1 proto-oncogene is sequestered in the cytoplasm of mammalian cancer cell lines
    Alao, John P.
    Gamble, Simon C.
    Stavropoulou, Alexandra V.
    Pomeranz, Karen M.
    Lam, Eric W-F
    Coombes, R. Charles
    Vigushin, David M.
    [J]. MOLECULAR CANCER, 2006, 5 (1)
  • [3] Cyclin D1 expression in B-cell non Hodgkin lymphoma
    Aref, Salah
    Mossad, Y.
    El-Khodary, T.
    Awad, M.
    El-Shahat, E.
    [J]. HEMATOLOGY, 2006, 11 (5-6) : 365 - 370
  • [4] Bales E, 2005, CANCER RES, V65, P692
  • [5] Cyclin E deregulation alters the biologic properties of ovarian cancer cells
    Bedrosian, I
    Lu, KH
    Verschraegen, C
    Keyomarsi, K
    [J]. ONCOGENE, 2004, 23 (15) : 2648 - 2657
  • [6] Human cytomegalovirus inhibits cellular DNA synthesis and arrests productively infected cells in late G1
    Bresnahan, WA
    Boldogh, I
    Thompson, EA
    Albrecht, T
    [J]. VIROLOGY, 1996, 224 (01) : 150 - 160
  • [7] BUCKLEY MF, 1993, ONCOGENE, V8, P2127
  • [8] Assembly of cyclin D-dependent kinase and titration of p27Kip1 regulated by mitogen-activated protein kinase kinase (MEK1)
    Cheng, MG
    Sexl, V
    Sherr, CJ
    Roussel, MF
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (03) : 1091 - 1096
  • [9] CHROMOSOMAL MAPPING OF THE GENES FOR THE HUMAN CELL-CYCLE PROTEINS CYCLIN-C (CCNC), CYCLIN-E (CCNE), P21 (CDKN1) AND KAP (CDKN3)
    DEMETRICK, DJ
    MATSUMOTO, S
    HANNON, GJ
    OKAMOTO, K
    XIONG, Y
    ZHANG, H
    BEACH, DH
    [J]. CYTOGENETICS AND CELL GENETICS, 1995, 69 (3-4): : 190 - 192
  • [10] Inhibition of cyclin D1 phosphorylation on threonine-286 prevents its rapid degradation via the ubiquintin-proteasome pathway
    Diehl, JA
    Zindy, F
    Sherr, CJ
    [J]. GENES & DEVELOPMENT, 1997, 11 (08) : 957 - 972
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