Synthesis of novel D-seco-taxoids derived from 1-deoxybaccatin VI

被引：4

作者：

Shao, Jun Chao ^{[1
]}

Ye, Zhi Hua ^{[1
]}

Lin, Hai Xia ^{[1
]}

Wang, Dian Long ^{[1
]}

Han, Na ^{[1
]}

机构：

[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2010年 / 21卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Taxoids; 1-Deoxybaccatin VI; Oxetane ring; Paclitaxel; BIOLOGICAL EVALUATION; DOCETAXEL; DERIVATIVES; RESISTANCE; ANALOGS;

D O I：

10.1016/j.cclet.2010.07.001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

New D-seco-taxoids were synthesized from 1-deoxybaccatin VI and their structures were confirmed by (1)H NMR, (13)C NMR, ESIMS and X-ray crystallography. The key step of the synthesis involved the opening of the oxetane ring under acid and basic conditions in order to obtain new multidrug resistance (MDR) reversal agents and new synthetic precursors of paclitaxel analogues. (C) 2010 Hai Xia Lin. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.

引用

页码：1273 / 1276

页数：4

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