Determining tissue optical properties by optical coherence tomography

Accurate measurement of tissue optical properties becomes more and more important in biomedical applications such as diagnostic imaging for tissue pathology. Taking account of multiple scattering effects in OCT model, an algorithm is developed to extract depth-resolved tissue optical properties including scattering coefficient and anisotropy factor. By adding absorption coefficient as the third fitting parameter in the algorithm, it is possible to reduce fitting errors introduced by sample absorption. With an adapted algorithm based on the extended model, absorption coefficient can also be extracted. The validity of those algorithms is verified by sample model of solution of polyethylene sphere (PS).