Evoked and event related coherence of Alzheimer patients manifest differentiation of sensory-cognitive networks

被引:60
作者
Basar, Erol [1 ]
Guntekin, Bahar [1 ]
Tulay, Elif [1 ]
Yener, Gorsev G. [2 ,3 ,4 ]
机构
[1] Istanbul Kultur Univ, Brain Dynam Cognit & Complex Syst Res Ctr, TR-34156 Istanbul, Turkey
[2] Dokuz Eylul Univ, Brain Dynam & Multidisciplinary Res Ctr, TR-35340 Izmir, Turkey
[3] Dokuz Eylul Univ, Dept Neurosci, TR-35340 Izmir, Turkey
[4] Dokuz Eylul Univ, Dept Neurol, TR-35340 Izmir, Turkey
关键词
Alzheimer; Evoked coherence; Event related coherence; Oddball paradigm; Brain oscillation; Cholinergic; TIME-FREQUENCY ANALYSIS; WORKING-MEMORY; EEG; OSCILLATIONS; DIAGNOSIS; DISEASE; THETA; SYNCHRONIZATION; IMPAIRMENT; POTENTIALS;
D O I
10.1016/j.brainres.2010.08.054
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In previous studies on Alzheimer's patients it was shown that, in frontal and parietal locations, delta and theta responses of AD patients were greatly reduced. The present study analyzed coherence functions in these highly affected frontal and parietal areas. Visual sensory and event related coherences of patients with Alzheimer type dementia (AD) were analyzed comparatively. A total of 38 mild, probable AD subjects (19 untreated, 19 treated with cholinesterase inhibitors) were compared with a group of 19 healthy controls. The sensory evoked coherence and event related target coherences were analyzed for delta (1-3.5 Hz), theta (4-7 Hz), alpha (8-13 Hz), beta (15-30 Hz) and gamma (28-48 Hz) frequency ranges for long-range intra-hemispheric (F-3-P-3, F-4-P-4, F-3-T-5, F-4-T-6, F-3-O-1, F-4-O-2) electrode pairs. The healthy control group showed significantly higher values of event related coherence in "delta", "theta" and "alpha" bands in comparison to the de nova and medicated AD groups (p<0.01 for the delta, theta and alpha) upon application of a target stimuli. In contrast, almost no changes in event related coherences were observed in beta and gamma frequency bands. Furthermore, no differences were recorded between healthy and AD groups upon application of simple light stimuli. Besides this, coherence values upon application of target stimuli were higher than sensory evoked coherence in all groups and in all frequency bands (p<0.01). The cognitive networks of AD patients were highly impaired in comparison to networks activated by sensory stimulation, thus showing separate activation of sensory and cognitive networks. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码:79 / 90
页数:12
相关论文
共 40 条
[1]   Resting EEG sources correlate with attentional span in mild cognitive impairment and Alzheimer's disease [J].
Babiloni, Claudio ;
Cassetta, Emanuele ;
Binetti, Giuliano ;
Tombini, Mario ;
Del Percio, Claudio ;
Ferreri, Florinda ;
Ferri, Raffaele ;
Frisoni, Giovanni ;
Lanuzza, Bartolo ;
Nobili, Flavio ;
Parisi, Laura ;
Rodriguez, Guido ;
Frigerio, Leonardo ;
Gurzi, Mariella ;
Prestia, Annapaola ;
Vernieri, Fabrizio ;
Eusebi, Fabrizio ;
Rossini, Paolo M. .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2007, 25 (12) :3742-3757
[2]   Frontal white matter volume and delta EEG sources negatively correlate in awake subjects with mild cognitive impairment and Alzheimer's disease [J].
Babiloni, Claudio ;
Frisoni, Giovanni ;
Steriade, Mircea ;
Bresciani, Lorena ;
Binetti, Giuliano ;
Del Percio, Claudio ;
Geroldi, Cristina ;
Miniussi, Carlo ;
Nobili, Flavio ;
Rodriguez, Guido ;
Zappasodi, Filippo ;
Carfagna, Tania ;
Rossini, Paolo A. .
CLINICAL NEUROPHYSIOLOGY, 2006, 117 (05) :1113-1129
[3]   Directionality of EEG synchronization in Alzheimer's disease subjects [J].
Babiloni, Claudio ;
Ferri, Raffaele ;
Binetti, Giuliano ;
Vecchio, Fabrizio ;
Frisoni, Giovanni B. ;
Lanuzza, Bartolo ;
Miniussi, Carlo ;
Nobili, Flavio ;
Rodriguez, Guido ;
Rundo, Francesco ;
Cassarino, Andrea ;
Infarinato, Francesco ;
Cassetta, Emanuele ;
Salinari, Serenella ;
Eusebi, Fabrizio ;
Rossini, Paolo M. .
NEUROBIOLOGY OF AGING, 2009, 30 (01) :93-102
[4]  
Basar E., 1980, EEG-Brain Dynamics. Relation between EEG and Brain Evoked Potentials
[5]   A review of brain oscillations in cognitive disorders and the role of neurotransmitters [J].
Basar, Erol ;
Guntekin, Bahar .
BRAIN RESEARCH, 2008, 1235 :172-193
[6]   A COMPOUND P300-40 HZ RESPONSE OF THE CAT HIPPOCAMPUS [J].
BASAREROGLU, C ;
BASAR, E .
INTERNATIONAL JOURNAL OF NEUROSCIENCE, 1991, 60 (3-4) :227-237
[7]   Tc-99m HMPAO SPECT in the differential diagnosis of the dementias with histopathologic confirmation [J].
Bonte, FJ ;
Harris, TS ;
Hynan, LS ;
Bigio, EH ;
White, CL .
CLINICAL NUCLEAR MEDICINE, 2006, 31 (07) :376-378
[8]   A comparative study of synchrony measures for the early diagnosis of Alzheimer's disease based on EEG [J].
Dauwels, J. ;
Vialatte, F. ;
Musha, T. ;
Cichocki, A. .
NEUROIMAGE, 2010, 49 (01) :668-693
[9]   Time-frequency analysis of single-sweep event-related potentials by means of fast wavelet transform [J].
Demiralp, T ;
Yordanova, J ;
Kolev, V ;
Ademoglu, A ;
Devrim, M ;
Samar, VJ .
BRAIN AND LANGUAGE, 1999, 66 (01) :129-145
[10]   Systematic review of the diagnostic accuracy of 99mTc-HWAO-SPECT in dementia [J].
Dougall, NJ ;
Bruggink, S ;
Ebmeier, KP .
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, 2004, 12 (06) :554-570