Benzene's toxicity: a consolidated short review of human and animal studies

被引：45
作者：
Khan, Haseeb Ahmad [1 ]
机构：
[1] King Saud Univ, Coll Sci, Dept Biochem, Riyadh 11451, Saudi Arabia
来源：
HUMAN & EXPERIMENTAL TOXICOLOGY | 2007年 / 26卷 / 09期
关键词：
benzene; chromosomal aberrations; cytotoxicity; genotoxicity; health hazards; mutations; sister chromatid exchange;
D O I：
10.1177/0960327107083974
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
A large population of humans is exposed to benzene from various occupational and environmental sources. Benzene is an established human and animal carcinogen. Exposure to benzene has been associated with leukaemia in humans and several types of malignancies in animals. The exact mechanism of benzene-induced toxicity is poorly understood. It is believed that benzene exerts its adverse effects by metabolic activation to toxic metabolites. Certain benzene metabolites are genotoxic and mutagenic. This consolidated short-review is composed of human and animal studies to summarize the adverse effects of benzene with special reference to molecular mechanisms involved in benzene-induced toxicity.
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收藏
页码：677 / 685
页数：9
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