Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis

被引：144

作者：

Collard, Harold R. ^{[2
]}

Calfee, Carolyn S. ^{[2
,3
,4
]}

Wolters, Paul J. ^{[2
]}

Song, Jin Woo ^{[1
]}

Hong, Sang-Bum ^{[1
]}

Brady, Sandra ^{[2
]}

Ishizaka, Akitoshi ^{[5
]}

Jones, Kirk D. ^{[6
]}

King, Talmadge E., Jr. ^{[2
]}

Matthay, Michael A. ^{[2
,3
,4
]}

Kim, Dong Soon ^{[1
]}

机构：

[1] Univ Ulsan, Dept Med, Seoul, South Korea

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA USA

[3] Univ Calif San Francisco, Dept Anesthesia, San Francisco, CA USA

[4] Univ Calif San Francisco, Inst Cardiovasc Res, San Francisco, CA USA

[5] Keio Univ, Dept Med, Tokyo, Japan

[6] Univ Calif San Francisco, Dept Pathol, San Francisco, CA USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY | 2010年 / 299卷 / 01期

关键词：

pulmonary fibrosis; respiratory distress syndrome; adult; biological markers; GLYCATION END-PRODUCTS; ACUTE LUNG INJURY; PROGNOSTIC-SIGNIFICANCE; RECEPTOR; OUTCOMES; MARKER; KL-6;

D O I：

10.1152/ajplung.90637.2008

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Collard HR, Calfee CS, Wolters PJ, Song JW, Hong S, Brady S, Ishizaka A, Jones KD, King TE, Jr, Matthay MA, Kim DS. Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 299: L3-L7, 2010. First published April 23, 2010; doi:10.1152/ajplung.90637.2008.-Little is known about the pathobiology of acute exacerbation of idiopathic pulmonary fibrosis (IPF), a condition that shares clinical and histopathological features with acute lung injury. Plasma biomarkers have been well studied in acute lung injury and have provided insight into the underlying disease mechanism. The objective of this study was to determine the plasma biomarker profile of acute exacerbation of IPF and compare this profile with that of stable IPF and acute lung injury. Plasma was collected from patients with stable IPF, acute exacerbation of IPF, and acute lung injury for measurement of biomarkers of cellular activity/injury (receptor for advanced glycation endproducts, surfactant protein D, KL-6, von Willebrand factor), systemic inflammation (IL-6), and coagulation/fibrinolysis (protein C, thrombomodulin, plasminogen activator inhibitor-1). Plasma from patients with acute exacerbation of IPF showed significant elevations in markers of type II alveolar epithelial cell injury and/or proliferation, endothelial cell injury, and coagulation. This profile differed from the biomarker profile in patients with acute lung injury. These findings support the hypothesis that type II alveolar epithelial cells are centrally involved in the pathobiology of acute exacerbation of IPF. Furthermore, they suggest that acute exacerbation of IPF has a distinct plasma biomarker profile from that of acute lung injury.

引用

页码：L3 / L7

页数：5

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