[18F]-Fluorodeoxyglucose PET/CT imaging as a marker of carotid plaque inflammation: Comparison to immunohistology and relationship to acuity of events

被引：42

作者：

Cocker, Myra S. ^{[1
,2
,16
]}

Spence, J. David ^{[3
,17
]}

Hammond, Robert ^{[4
,18
]}

deKemp, Robert A. ^{[1
,2
,16
]}

Lum, Cheemun ^{[5
,6
,19
]}

Wells, George ^{[7
,16
]}

Bernick, Jordan ^{[7
,16
]}

Hill, Andrew ^{[7
,19
]}

Nagpal, Sudhir ^{[6
,8
,19
]}

Stotts, Grant ^{[6
,9
,19
]}

Alturkustani, Murad ^{[4
,18
]}

Adeeko, Adebayo ^{[10
,20
]}

Yerofeyeva, Yulia ^{[10
,20
]}

Rayner, Katey ^{[12
,16
]}

Peterson, Joan ^{[6
,7
]}

Khan, Ali R. ^{[14
,18
]}

Naidas, Ann C. ^{[4
,18
]}

Garrard, Linda ^{[16
]}

Yaffe, Martin J. ^{[20
]}

Leung, Eugene ^{[6
,11
,19
]}

Prato, Frank S. ^{[15
]}

Tardif, Jean-Claude ^{[13
,21
]}

Beanlands, Rob S. B. ^{[5
,6
,11
]}

机构：

[1] Univ Ottawa, Heart Inst, Dept Med, Div Cardiol,Mol Funct & Imaging Program, Ottawa, ON, Canada

[2] Univ Ottawa, Heart Inst, Dept Med, Natl Cardiac PET Ctr, Ottawa, ON, Canada

[3] Western Univ, Robarts Res Inst, Stroke Prevent & Atherosclerosis Res Ctr, London, ON, Canada

[4] Western Univ, Dept Pathol, London, ON, Canada

[5] Univ Ottawa, Dept Radiol, Ottawa, ON, Canada

[6] Ottawa Hosp, Civ Campus,1053 Carling Ave,C2184, Ottawa, ON K1Y 4E9, Canada

[7] Univ Ottawa, Heart Inst, Cardiovasc Res Methods Ctr, Ottawa, ON, Canada

[8] Univ Ottawa, Dept Surg, Div Vasc Surg, Ottawa, ON, Canada

[9] Univ Ottawa, Dept Med, Div Neurol, Ottawa, ON, Canada

[10] Univ Toronto, Sunnybrook Hlth Sci Ctr, Sunnybrook Res Inst, Toronto, ON, Canada

[11] Univ Ottawa, Dept Med, Div Nucl Med, Ottawa, ON, Canada

[12] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON, Canada

[13] Univ Montreal, Montreal Heart Inst, Div Cardiol, Montreal, PQ, Canada

[14] Western Univ, Robarts Res Inst, Dept Med Biophys, London, ON, Canada

[15] Lawson Hlth Res Inst, 268 Grosvenor St, London, ON N6A 4V2, Canada

[16] Univ Ottawa, Heart Inst, Natl Cardiac PET Ctr, 40 Ruskin St, Ottawa, ON K1Y 4W7, Canada

[17] Robarts Res Inst, 1400 Western Rd, London, ON N6G 2V4, Canada

[18] Western Univ, Richmond St N, Richmond, ON N6A 5C1, Canada

[19] Univ Ottawa, Ottawa Hosp, 1053 Carling Ottawa, Ottawa, ON K1Y 4E9, Canada

[20] Sunnybrook Res Inst, Bayview Ave, Toronto, ON M4N 3M5, Canada

[21] Montreal Heart Inst, 5000 Belanger St, Montreal, PQ H1T 1C8, Canada

来源：

INTERNATIONAL JOURNAL OF CARDIOLOGY | 2018年 / 271卷

关键词：

(18)FDG PET/CT; 18-F]-fluorodeoxyglucose; Carotid plaque inflammation; Macrophage; Leukocyte; Acuity; Symptoms; POSITRON-EMISSION-TOMOGRAPHY; ISCHEMIC CEREBROVASCULAR EVENTS; EARLY RISK; ATHEROSCLEROTIC PLAQUES; ARTERY-DISEASE; STROKE; CELLS; VULNERABILITY; MACROPHAGES; RECURRENCE;

D O I：

10.1016/j.ijcard.2018.05.057

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: [18F]-fluorodeoxyglucose ((18)FDG) uptake imaged with positron emission tomography (PET) and computed tomography (CT) may serve as a biomarker of plaque inflammation. This study evaluated the relationship between carotid plaque (18)FDG uptake and a) intraplaque expression of macrophage and macrophage-like cellular CD68 immunohistology; b) intraplaque inflammatory burden using leukocyte-sensitive CD45 immunohistology; c) symptomatic patient presentation; d) time from last cerebrovascular event. Methods: 54 patients scheduled for carotid endarterectomy underwent 18FDG PET/CT imaging. Maximum 18FDG uptake (SUVmax) and tissue-to-blood ratio (TBRmax) was measured for carotid plaques. Quantitative immunohistological analysis of macrophage-like cell expression (CD68) and leukocyte content (CD45) was performed. Results: 18FDGuptakewas related to CD68 macrophage expression (TBRmax: r=0.51, p < 0.001), and total-plaque leukocyte CD45 expression (TBRmax: r=0.632, p=0.009, p < 0.001). 18FDG TBRmax uptake in carotid plaque associated with patient symptoms was greater than asymptomatic plaque (3.58 +/- 1.01 vs. 3.13 +/- 1.10, p=0.008). 18FDG uptake differed between an acuity threshold of >90 days and >90 days (SUVmax: 3.15 +/- 0.87 vs. 2.52 +/- 0.45, p=0.015). Conclusions: In this CAIN cohort, 18FDG uptake imaged with PET/CT serves a surrogate marker of intraplaque inflammatory macrophage, macrophage-like cell and leukocyte burden. 18FDG uptake is greater in plaque associated with patient symptoms and those with recent cerebrovascular events. Future studies are needed to relate 18FDG uptake and disease progression. (c) 2018 Elsevier B.V. All rights reserved.

引用

页码：378 / 386

页数：9

共 33 条

[31] Atherosclerotic plaque progression and vulnerability to rupture - Angiogenesis as a source of intraplaque hemorrhage [J].