Healing properties of some Indian medicinal plants against indomethacin-induced gastric ulceration of rats

被引：59
作者：
Bhattacharya, Sayanti
Chaudhuri, Susri R.
Chattopadhyay, Subrata
Bandyopadhyay, Sandip K.
机构：
[1] Post Grad Inst Basic Med Sci, Dept Biochem, IPGMERR, Kolkata 700020, India
[2] Bhabha Atom Res Ctr, Div Bioorgan, Bombay 400085, Maharashtra, India
来源：
JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | 2007年 / 41卷 / 02期
关键词：
antioxidant; Indian medicinal plants; indomethacin; mucin; stomach ulcer;
D O I：
10.3164/jcbn.2007015
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
The healing activity of the ethanol extracts of Piper betel, Emblica officinalis, Terminalia bellerica, and Terminalia chebula against the indomethacin-induced stomach ulceration has been studied and compared with that of misoprostol. Compared to autohealing, all the drugs accelerated the healing process, albeit to different extents. The relative healing activities of the extracts was A betel>E. officinalis>T. bellerica similar to T. chebula, that correlated well with their in vivo antioxidant and mucin augmenting activities. The excellent healing activity of the extracts of P. betel and E. officinalis indicated a major role of mucin protection and regeneration in the healing of nonsteroidal anti-inflammatory drugs mediated stomach ulceration.
引用
收藏
页码：106 / 114
页数：9
相关论文
共 33 条
[1]   Gastroprotective effects of 'Amla' Emblica officinalis on in vivo test models in rats [J].
Al-Rehaily, AJ ;
Al-Howiriny, TA ;
Al-Sohaibani, MO ;
Rafatullah, S .
PHYTOMEDICINE, 2002, 9 (06) :515-522
[2]   Modulation of arachidonic acid metabolism by phenols:: Relation to their structure and antioxidant/prooxidant properties [J].
Alanko, J ;
Riutta, A ;
Holm, P ;
Mucha, I ;
Vapaatalo, H ;
Metsä-Ketelä, T .
FREE RADICAL BIOLOGY AND MEDICINE, 1999, 26 (1-2) :193-201
[3]   3,4,5-trihydroxy benzoic acid (gallic acid), the hepatoprotective principle in the fruits of Terminalia belerica bioassay guided activity [J].
Anand, KK ;
Singh, B ;
Saxena, AK ;
Chandan, BK ;
Gupta, VN ;
Bhardwaj, V .
PHARMACOLOGICAL RESEARCH, 1997, 36 (04) :315-321
[4]   The role of antioxidant activity of Phyllanthus emblica fruits on prevention from indomethacin induced gastric ulcer [J].
Bandyopadhyay, SK ;
Pakrashi, SC ;
Pakrashi, A .
JOURNAL OF ETHNOPHARMACOLOGY, 2000, 70 (02) :171-176
[5]  
BERNIER JJ, 1986, RECHERCHE, V17, P614
[6]  
Bhattacharya Arunabh, 2000, Indian Journal of Experimental Biology, V38, P877
[7]   Inhibitory property of Piper betel extract against photosensitization-induced damages to lipids and proteins [J].
Bhattacharya, S. ;
Mula, S. ;
Gamre, S. ;
Kamat, J. P. ;
Bandyopadhyay, S. K. ;
Chattopadhyay, S. .
FOOD CHEMISTRY, 2007, 100 (04) :1474-1480
[8]   Radioprotective property of the ethanolic extract of Piper betel leaf [J].
Bhattacharya, S ;
Subramanian, M ;
Roychowehury, S ;
Baur, AK ;
Kamat, JP ;
Chattopadhyay, S ;
Bandyopadhyay, SK .
JOURNAL OF RADIATION RESEARCH, 2005, 46 (02) :165-171
[9]   Effect of bioactive tannoid principles of Emblica officinalis on ischemia-reperfusion-induced oxidative stress in rat heart [J].
Bhattacharya, SK ;
Bhattacharya, A ;
Sairam, K ;
Ghosal, S .
PHYTOMEDICINE, 2002, 9 (02) :171-174
[10]   A novel antioxidant and antiapoptotic role of omeprazole to block gastric ulcer through scavenging of hydroxyl radical [J].
Biswas, K ;
Bandyopadhyay, U ;
Chattopadhyay, I ;
Varadaraj, A ;
Ali, E ;
Banerjee, RK .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (13) :10993-11001
1234