Cell-Based and Scaffold-Based Therapies for Joint Preservation in Early-Stage Osteonecrosis of the Femoral Head A Review of Basic Research

被引：13

作者：

Maruyama, Masahiro ^{[1
,2
]}

Lin, Tzuhua ^{[1
,2
]}

Pan, Chi-Chun ^{[1
,2
,5
]}

Moeinzadeh, Seyedsina ^{[1
,2
]}

Takagi, Michiaki ^{[1
,6
]}

Yang, Yunzhi Peter ^{[1
,2
,3
,4
]}

Goodman, Stuart B. ^{[1
,2
,4
]}

机构：

[1] Stanford Univ, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Dept Orthopaed Surg, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Dept Mat Sci & Engn, Stanford, CA 94305 USA

[4] Stanford Univ, Sch Med, Dept Bioengn, Stanford, CA 94305 USA

[5] Stanford Univ, Dept Mech Engn, Sch Engn, Stanford, CA 94305 USA

[6] Yamagata Univ, Dept Orthopaed Surg, Fac Med, Yamagata, Japan

来源：

JBJS REVIEWS | 2019年 / 7卷 / 09期

基金：

美国国家卫生研究院;

关键词：

MESENCHYMAL STEM-CELLS; GLUCOCORTICOID-INDUCED OSTEONECROSIS; MARROW MONONUCLEAR-CELLS; NF-KAPPA-B; BONE-MARROW; AVASCULAR NECROSIS; STROMAL CELLS; CORE DECOMPRESSION; RABBIT MODEL; INTRAVENOUS TRANSPLANTATION;

D O I：

10.2106/JBJS.RVW.18.00202

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Numerous basic-science and translational studies of cell-based and scaffold-based therapies are currently being performed. The advantages and limitations of cell-based therapy for osteonecrosis of the femoral head, including bone marrow-derived mononuclear cells (BM-MNCs), mesenchymal stem cells (MSCs), and MSC-derived exosomes, are being examined preclinically. A range of ceramic-based, polymer-based, hydrogel-based, and composite scaffolds have been used for the treatment of osteonecrosis of the femoral head in order to physically or functionally support bone repair and remodeling. Modulation of the pro-inflammatory response at an appropriate time point has enhanced bone formation in experimental models. The therapeutic potential of these strategies in translational models of osteonecrosis of the femoral head has not been fully clarified.

引用

页数：10

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[1] IL-4 abrogates osteoclastogenesis through STAT6-dependent inhibition of NF-κB [J].