A gold nanoparticles - Graphene based electrochemical sensor for sensitive determination of nitrazepam

被引：37

作者：

Fritea, Luminita ^{[1
]}

Banica, Florin ^{[2
]}

Costea, Traian Octavian ^{[3
]}

Moldovan, Liviu ^{[4
]}

Iovan, Ciprian ^{[1
]}

Cavalu, Simona ^{[1
]}

机构：

[1] Univ Oradea, Preclin Disciplines Dept, Fac Med & Pharm, 10 Piata 1 Decembrie St, Oradea 410073, Romania

[2] Univ Oradea, Pharm Dept, Fac Med & Pharm, 29 Nicolae Jiga St, Oradea 410028, Romania

[3] Univ Oradea, Adv Mat Res Lab, 1 Univ St, Oradea 410087, Romania

[4] Univ Oradea, Elect & Telecommun Dept, Fac Elect Engn & Informat Technol, 1 Univ St, Oradea 410087, Romania

来源：

JOURNAL OF ELECTROANALYTICAL CHEMISTRY | 2018年 / 830卷

关键词：

Reduced graphene oxide; Gold nanoparticles; Electrodeposition; Nitrazepam; Voltammetry; Sensor; ELECTRODE; OXIDE; CHROMATOGRAPHY; BENZODIAZEPINES; FLUNITRAZEPAM; NANOMATERIALS; BIOSENSORS; COMPOSITE; BEHAVIOR; RISK;

D O I：

10.1016/j.jelechem.2018.10.015

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A new nanoplatform based on reduced graphene oxide decorated with electrochemically generated gold nanoparticles was developed for sensitive and selective determination of nitrazepam. This nanostructure was characterized by Fourier transform infrared spectroscopy, atomic force microscopy, scanning electron microscopy coupled with energy dispersive X-ray spectroscopy and electrochemical methods. The synergic effect of the two nanomaterials gives an electrode platform with a high surface area, good conductivity and excellent catalytic properties. The sensor exhibited a wide linear range (0.5 mu M-400 mu M), low limit of detection (0.166 mu M), excellent sensitivity, good selectivity, and high stability for nitrazepam determination in serum and a pharmaceutical formulation with excellent recovery rates (99%-102.4%).

引用

页码：63 / 71

页数：9

共 44 条

[1]

Ali S. M., 2017, INT J CHEMTECH RES, V10, P749

[2]

Aliofkhazraei M., 2016, GRAPHENE SCI HDB FAB

[3]

Atta N.F., 2015, BIOSENSORS MICRO NAN, DOI DOI 10.5772/60676

[4] Quantitative determination of diazepam, nitrazepam and flunitrazepam in tablets using thin-layer chromatography-densitometry technique [J].

Bakavoli, M ;

Kaykhaii, M .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2003, 31 (06) :1185-1189

[5]

Banica F., 2007, CONSTRUCTION EVALUAT, P207

[6]

Cernat A., 2016, ADV 2D MAT 3, P387

[7] Boron-doped Graphene quantum dots modified electrode for electrochemistry and electrocatalysis of hemoglobin [J].

Chen, Wei ;

Weng, Wenju ;

Niu, Xueliang ;

Li, Xiaoyan ;

Men, Yongling ;

Sun, Wei ;

Li, Guangjiu ;

Dong, Lifeng .

JOURNAL OF ELECTROANALYTICAL CHEMISTRY, 2018, 823 :137-145

[8] Flow-injection fluorimetric determination of 1,4-benzodiazepines in pharmaceutical formulations after acid hydrolysis [J].

Dolejsová, J ;

Solich, P ;

Polydorou, CK ;

Koupparis, MA ;

Efstathiou, CE .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 1999, 20 (1-2) :357-362

[9] Robust Electrografting on Self-Organized 3D Graphene Electrodes [J].

Fortgang, Philippe ;

Tite, Teddy ;

Barnier, Vincent ;

Zehani, Nedjla ;

Maddi, Chiranjeevi ;

Lagarde, Florence ;

Loir, Anne-Sophie ;

Jaffrezic-Renault, Nicole ;

Donnet, Christophe ;

Garrelie, Florence ;

Chaix, Carole .

ACS APPLIED MATERIALS & INTERFACES, 2016, 8 (02) :1424-1433

[10]

Fritea L, 2015, INT J ELECTROCHEM SC, V10, P7292

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