Supplementation with NAD+ and Its Precursors to Prevent Cognitive Decline across Disease Contexts

被引:28
作者
Campbell, Jared M. [1 ]
机构
[1] Univ New South Wales Sydney, Grad Sch Biomed Engn, Sydney, NSW 2052, Australia
基金
澳大利亚研究理事会;
关键词
cognitive health; cognitive decline; neuroprotection; NAD; NADH; nicotinamide riboside; nicotinamide mono nucleotide; nicotinamide; dementia; stroke; diabetes; traumatic brain injury; NICOTINAMIDE ADENINE-DINUCLEOTIDE; TRAUMATIC BRAIN-INJURY; IMPROVES FUNCTIONAL RECOVERY; WATER MAZE PERFORMANCE; BEHAVIORAL RECOVERY; NEURONAL SURVIVAL; OXIDATIVE STRESS; UNITED-STATES; RAT MODEL; IMPAIRMENT;
D O I
10.3390/nu14153231
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The preservation of cognitive ability by increasing nicotinamide adenine dinucleotide (NAD(+)) levels through supplementation with NAD(+) precursors has been identified as a promising treatment strategy for a number of conditions; principally, age-related cognitive decline (including Alzheimer's disease and vascular dementia), but also diabetes, stroke, and traumatic brain injury. Candidate factors have included NAD(+) itself, its reduced form NADH, nicotinamide (NAM), nicotinamide mononucleotide (NMN), nicotinamide riboside (NR), and niacin (or nicotinic acid). This review summarises the research findings for each source of cognitive impairment for which NAD(+) precursor supplementation has been investigated as a therapy. The findings are mostly positive but have been made primarily in animal models, with some reports of null or adverse effects. Given the increasing popularity and availability of these factors as nutritional supplements, further properly controlled clinical research is needed to provide definitive answers regarding this strategy's likely impact on human cognitive health when used to address different sources of impairment.
引用
收藏
页数:11
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