A focus on the association of Apol1 with kidney disease in children

被引：12

作者：

Ekulu, Pepe M. ^{[1
,2
]}

Nkoy, Agathe B. ^{[2
]}

Adebayo, Oyindamola C. ^{[1
]}

Kazadi, Orly K. ^{[2
]}

Aloni, Michel N. ^{[2
]}

Arcolino, Fanny O. ^{[1
]}

Ngiyulu, Rene M. ^{[2
]}

Gini, Jean-Lambert E. ^{[2
]}

Lepira, Francois B. ^{[3
]}

van den Heuvel, Lamberthus P. ^{[1
,4
]}

Levtchenko, Elena N. ^{[5
,6
]}

机构：

[1] Katholieke Univ Leuven, Dept Dev & Regenerat, Leuven, Belgium

[2] Univ Kinshasa, Div Nephrol, Dept Pediat, Fac Med,Univ Hosp Kinshasa, Kinshasa, DEM REP CONGO

[3] Univ Kinshasa, Div Nephrol, Dept Internal Med, Fac Med,Univ Hosp Kinshasa, Kinshasa, DEM REP CONGO

[4] Radboud Univ Nijmegen, Dept Pediat Nephrol, Med Ctr, Nijmegen, Netherlands

[5] Katholieke Univ Leuven, Dept Pediat Nephrol, Univ Hosp Leuven, Leuven, Belgium

[6] Katholieke Univ Leuven, Dept Dev & Regenerat, Univ Hosp Leuven, Leuven, Belgium

来源：

PEDIATRIC NEPHROLOGY | 2021年 / 36卷 / 04期

关键词：

APOL1; Chronic kidney disease; Children; Genetics; Sickle cell disease; HIV-associated nephropathy; STAGE RENAL-DISEASE; AFRICAN-AMERICAN CHILDREN; RISK VARIANTS; APOLIPOPROTEIN L1; NEPHROPATHY; GENE; GENOTYPE; OUTCOMES; ALLELES; ADULTS;

D O I：

10.1007/s00467-020-04553-z

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Individuals of African origin have an increased risk of developing various progressive chronic kidney diseases (CKD). This risk has been attributed to genetic variants (G1, G2) in apolipoprotein-L1 (APOL1) gene. In the pediatric population, especially in children affected by sickle cell disease (SCD), by human immunodeficiency virus (HIV), or with various glomerular diseases, APOL1 risk variants have been associated with the development of hypertension, albuminuria, and more rapid decline of kidney function. The present review focuses on existing APOL1-related epidemiological data in children with CKD. It also includes data from studies addressing racial disparities in CKD, the APOL1-related innate immunity, and the relationship between APOL1 and CKD and pathogenic pathways mediating APOL1-related kidney injury.

引用

页码：777 / 788

页数：12

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