The dopaminergic reward system underpins gender differences in social preferences

被引：100

作者：

Soutschek, Alexander ^{[1
]}

Burke, Christopher J. ^{[1
]}

Beharelle, Anjali Raja ^{[1
]}

Schreiber, Robert ^{[1
]}

Weber, Susanna C. ^{[1
]}

Karipidis, Iliana I. ^{[1
,2
,3
]}

ten Velden, Jolien ^{[1
,4
]}

Weber, Bernd ^{[5
,6
]}

Haker, Helene ^{[7
,8
]}

Kalenscher, Tobias ^{[9
]}

Tobler, Philippe N. ^{[1
,3
]}

机构：

[1] Univ Zurich, Dept Econ, Lab Social & Neural Syst Res, CH-8006 Zurich, Switzerland

[2] Univ Zurich, Hosp Psychiat, Dept Child & Adolescent Psychiat & Psychotherapy, CH-8032 Zurich, Switzerland

[3] Univ Zurich, Swiss Fed Inst Technol Zurich, Neurosci Ctr Zurich, CH-8057 Zurich, Switzerland

[4] Max Planck Inst Psycholinguist, NL-6525 XD Nijmegen, Netherlands

[5] Univ Hosp Bonn, Dept Epileptol, D-53105 Bonn, Germany

[6] Univ Bonn, Ctr Econ & Neurosci, D-53127 Bonn, Germany

[7] Univ Zurich, Translat Neuromodeling Unit, Inst Biomed Engn, CH-8032 Zurich, Switzerland

[8] Swiss Fed Inst Technol, CH-8032 Zurich, Switzerland

[9] Heinrich Heine Univ, Inst Expt Psychol, Comparat Psychol, D-40225 Dusseldorf, Germany

来源：

NATURE HUMAN BEHAVIOUR | 2017年 / 1卷 / 11期

基金：

瑞士国家科学基金会;

关键词：

VICARIOUS REWARD; BEHAVIOR; HUMANS; TIME; AMISULPRIDE; RECEPTORS; SEROTONIN; SIGNALS; METAANALYSIS; IMPULSIVITY;

D O I：

10.1038/s41562-017-0226-y

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

Women are known to have stronger prosocial preferences than men, but it remains an open question as to how these behavioural differences arise from differences in brain functioning. Here, we provide a neurobiological account for the hypothesized gender difference. In a pharmacological study and an independent neuroimaging study, we tested the hypothesis that the neural reward system encodes the value of sharing money with others more strongly in women than in men. In the pharmacological study, we reduced receptor type-specific actions of dopamine, a neurotransmitter related to reward processing, which resulted in more selfish decisions in women and more prosocial decisions in men. Converging findings from an independent neuroimaging study revealed gender-related activity in neural reward circuits during prosocial decisions. Thus, the neural reward system appears to be more sensitive to prosocial rewards in women than in men, providing a neurobiological account for why women often behave more prosocially than men.

引用

页码：819 / 827

页数：9

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[1] Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo [J].