Impact of Oxysterols on Cell Death, Proliferation, and Differentiation Induction: Current Status

被引：50
作者：
de Freitas, Fabio Alessandro [1 ]
Levy, Debora [1 ]
Zarrouk, Amira [2 ,3 ]
Lizard, Gerard [4 ]
Bydlowski, Sergio Paulo [1 ,5 ]
机构：
[1] Univ Sao Paulo, Fac Med, Heart Inst InCor, Lab Immunol LIM19,Lipids Oxidat & Cell Biol Team, BR-05403900 Sao Paulo, Brazil
[2] Univ Monastir, Lab NAFS Nutr Funct Food & Vasc Hlth, Fac Med, LR12ES05, Monastir 5000, Tunisia
[3] Univ Sousse, Fac Med, Sousse 5000, Tunisia
[4] Univ Bourgogne Franche Comte, Inst Natl Sante & Rech Med Inserm, Team Biochem Peroxisome Inflammat & Lipid Metab E, F-7270 Dijon, France
[5] CNPq, Natl Inst Sci & Technol Regenerat Med INCT Regene, BR-21941902 Rio De Janeiro, Brazil
来源：
CELLS | 2021年 / 10卷 / 09期
基金：
巴西圣保罗研究基金会;
关键词：
apoptosis; autophagy; cell death; differentiation; oxysterols; mesenchymal stem cells; oxiapoptophagy; INDUCED OSTEOGENIC DIFFERENTIATION; CHOLESTEROL OXIDATION-PRODUCTS; IN-VITRO; APOPTOSIS; 7-KETOCHOLESTEROL; AUTOPHAGY; CANCER; METABOLISM; 7-BETA-HYDROXYCHOLESTEROL; 27-HYDROXYCHOLESTEROL;
D O I：
10.3390/cells10092301
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Oxysterols are oxidized derivatives of cholesterol produced by enzymatic activity or non-enzymatic pathways (auto-oxidation). The oxidation processes lead to the synthesis of about 60 different oxysterols. Several oxysterols have physiological, pathophysiological, and pharmacological activities. The effects of oxysterols on cell death processes, especially apoptosis, autophagy, necrosis, and oxiapoptophagy, as well as their action on cell proliferation, are reviewed here. These effects, also observed in several cancer cell lines, could potentially be useful in cancer treatment. The effects of oxysterols on cell differentiation are also described. Among them, the properties of stimulating the osteogenic differentiation of mesenchymal stem cells while inhibiting adipogenic differentiation may be useful in regenerative medicine.
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页数：20
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