Medical gas plasma-stimulated wound healing: Evidence and mechanisms

被引：130

作者：

Bekeschus, Sander ^{[1
]}

von Woedtke, Thomas ^{[1
,2
]}

Emmert, Steffen ^{[3
]}

Schmidt, Anke ^{[1
]}

机构：

[1] Leibniz Inst Plasma Sci & Technol INP, ZIK Plasmatis, Felix Hausdorff Str 2, D-17489 Greifswald, Germany

[2] Greifswald Univ, Inst Hyg & Environm Med, Med Ctr, Sauerbruchstr, D-17475 Greifswald, Germany

[3] Rostock Univ Med Ctr, Clin Dermatol & Venereol, Strempelstr 13, D-18057 Rostock, Germany

来源：

REDOX BIOLOGY | 2021年 / 46卷

关键词：

Defective healing; Dermatology; Plasma medicine; Reactive oxygen and nitrogen species; RNS; ROS; Ulcers; COLD ATMOSPHERIC PLASMA; CHRONIC DIABETIC ULCERS; ARGON PLASMA; GROWTH-FACTORS; PSEUDOMONAS-AERUGINOSA; HUMAN KERATINOCYTES; HYDROGEN-PEROXIDE; OXIDATIVE STRESS; CLINICAL-TRIAL; TISSUE-REPAIR;

D O I：

10.1016/j.redox.2021.102116

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Defective wound healing poses a significant burden on patients and healthcare systems. In recent years, a novel reactive oxygen and nitrogen species (ROS/RNS) based therapy has received considerable attention among dermatologists for targeting chronic wounds. The multifaceted ROS/RNS are generated using gas plasma technology, a partially ionized gas operated at body temperature. This review integrates preclinical and clinical evidence into a set of working hypotheses mainly based on redox processes aiding in elucidating the mechanisms of action and optimizing gas plasmas for therapeutic purposes. These hypotheses include increased wound tissue oxygenation and vascularization, amplified apoptosis of senescent cells, redox signaling, and augmented microbial inactivation. Instead of a dominant role of a single effector, it is proposed that all mechanisms act in concert in gas plasma-stimulated healing, rationalizing the use of this technology in therapy-resistant wounds. Finally, addressable current challenges and future concepts are outlined, which may further promote the clinical utilization, efficacy, and safety of gas plasma technology in wound care in the future.

引用

页数：17

共 197 条

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