Oximoaspergillimide, a Fungal Derivative from a Marine Isolate of Aspergillus sp.

被引：17

作者：

Cardoso-Martinez, Faviola ^{[1
]}

de la Rosa, Jose M. ^{[1
]}

Diaz-Marrero, Ana R. ^{[1
]}

Darias, Jose ^{[1
]}

D'Croz, Luis ^{[2
,3
]}

Cerella, Claudia ^{[2
,4
]}

Diederich, Marc ^{[5
]}

Cueto, Mercedes ^{[1
]}

机构：

[1] CSIC, Inst Prod Nat & Agrobiol, Tenerife 38206, Spain

[2] Univ Panama, Dept Biol Marina & Limnol, Panama City, Panama

[3] Smithsonian Trop Res Inst, Balboa, Panama

[4] Hop Kirchberg, Lab Biol Mol & Cellulaire Canc, L-2540 Luxembourg, Luxembourg

[5] Seoul Natl Univ, Coll Pharm, Seoul 151742, South Korea

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 2015卷 / 10期

基金：

新加坡国家研究基金会;

关键词：

Natural products; Structure elucidation; Alkaloids; Oximes; Antimicrobial activity; Cytotoxicity; SEDIMENT-DERIVED FUNGUS; ALGICOLOUS ISOLATE; METABOLITES; BIOSYNTHESIS; STEROIDS;

D O I：

10.1002/ejoc.201403668

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new alkaloid, oximoaspergillimide (1), and the known neohydroxyaspergillic (2) and neoaspergillic (3) acids, have been isolated from the extract of a cultured marine-derived fungus (strain CF07002) identified as a member of the genus Aspergillus. The structure of 1 was determined by interpretation of NMR spectroscopic data, and confirmed by synthesis. The antimicrobial and cytotoxic activities of compounds 1-3 were evaluated.

引用

页码：2256 / 2261

页数：6

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