New Genetics and Genomic Data on Pancreatic Neuroendocrine Tumors: Implications for Diagnosis, Treatment, and Targeted Therapies

被引：11

作者：

Schmitt, Anja M. ^{[1
]}

Marinoni, Ilaria ^{[1
]}

Blank, Annika ^{[1
]}

Perren, Aurel ^{[1
]}

机构：

[1] Univ Bern, Inst Pathol, Murtenstr 31, CH-3010 Bern, Switzerland

来源：

ENDOCRINE PATHOLOGY | 2016年 / 27卷 / 03期

关键词：

Review; Pancreatic neuroendocrine tumor; DAXX/ATRX; Epigenetics; Methylation; Alternative lengthening of telomeres; DNA METHYLATION; DAXX; TELOMERES; ATRX; INSTABILITY; INHIBITORS; PROGNOSIS; CELLS; MEN1;

D O I：

10.1007/s12022-016-9447-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The recent findings on the roles of death-associated protein 6/alpha-thalassemia/mental retardation X-linked (DAXX/ATRX) in the development of pancreatic neuroendocrine tumors (PanNETs) have led to major advances in the molecular understanding of these rare tumors and open up completely new therapeutic windows. This overview aims at giving a simplified view on these findings and their possible therapeutic implications. The importance of epigenetic changes in PanNET is also underlined by recent findings of a cross-species study on microRNA (miRNA) and messenger RNA (mRNA) profiles in PanNETs.

引用

页码：200 / 204

页数：5

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